FeMn and FeMnAg biodegradable alloys: An in vitro and in vivo investigation

Saliba, Luke; Sammut, Keith; Tonna, Christabelle; Pavli, Foteini; Valdramidis, Vasilis; Gatt, Ray; Giordmaina, Ryan; Camilleri, Liberato; Atanasio, William; Buhagiar, Joseph; Schembri-Wismayer, Pierre

doi:10.1016/j.heliyon.2023.e15671

Cited by 7 publications

(3 citation statements)

References 70 publications

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“…coli, − S. aureus, , or both strains as well as various staphylococci strains . Therefore, FeMnC-based alloys were evaluated for the first time regarding their antibacterial behavior against P.…”

Section: Discussionmentioning

confidence: 99%

“…Studies investigating the antibacterial effect of Cu or Ag in Fe-based alloys, considered only one bacteria strain for their testing, either E. coli , 33 − 36 S. aureus, 37 , 56 or both strains 57 as well as various staphylococci strains. 58 Therefore, FeMnC-based alloys were evaluated for the first time regarding their antibacterial behavior against P. aeruginosa in this study. Additionally, clinically applied AISI 316L stainless steel was used as reference material for all three bacterial strains in comparison to the FeMnC-based alloys, whereas other studies analyzing Cu-containing Fe-based alloys utilized only either pure Fe, 34 FeMn, 36 a positive control, 35 or no control.…”

Section: Discussionmentioning

confidence: 99%

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Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Paul,

Kiel,

Otto

et al. 2024

ACS Appl. Bio Mater.

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Implant-related infections or inflammation are one of the main reasons for implant failure. Therefore, different concepts for prevention are needed, which strongly promote the development and validation of improved material designs. Besides modifying the implant surface by, for example, antibacterial coatings (also implying drugs) for deterring or eliminating harmful bacteria, it is a highly promising strategy to prevent such implant infections by antibacterial substrate materials. In this work, the inherent antibacterial behavior of the as-cast biodegradable Fe69Mn30C1 (FeMnC) alloy against Gram-negative Pseudomonas aeruginosa and Escherichia coli as well as Gram-positive Staphylococcus aureus is presented for the first time in comparison to the clinically applied, corrosion-resistant AISI 316L stainless steel. In the second step, 3.5 wt % Cu was added to the FeMnC reference alloy, and the microbial corrosion as well as the proliferation of the investigated bacterial strains is further strongly influenced. This leads for instance to enhanced antibacterial activity of the Cu-modified FeMnC-based alloy against the very aggressive, wild-type bacteria P. aeruginosa. For clarification of the bacterial test results, additional analyses were applied regarding the microstructure and elemental distribution as well as the initial corrosion behavior of the alloys. This was electrochemically investigated by a potentiodynamic polarization test. The initial degraded surface after immersion were analyzed by glow discharge optical emission spectrometry and transmission electron microscopy combined with energy-dispersive X-ray analysis, revealing an increase of degradation due to Cu alloying. Due to their antibacterial behavior, both investigated FeMnC-based alloys in this study are attractive as a temporary implant material.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Paul,

Kiel,

Otto

et al. 2024

ACS Appl. Bio Mater.

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“…XRD results from the alloys’ surfaces after immersion periods confirmed the corrosion process starting from day one, after which immersion peaks of FeOOH, MnOOH, FeCO 3 , MnCO 3 and CaCO 3 can be observed [ 68 ]. The presence of ε-martensite phase ( Figure 8 b) increases the degradation rate of the material, forming micro-piles between material different phase constituents.…”

Section: Discussionmentioning

confidence: 99%

Investigations on the Degradation Behavior of Processed FeMnSi-xCu Shape Memory Alloys

Roman,

Cimpoeșu,

Pricop

et al. 2024

Nanomaterials

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A new functional Fe-30Mn-5Si-xCu (x = 1.5 and 2 wt%) biomaterial was obtained from the levitation induction melting process and evaluated as a biodegradable material. The degradation characteristics were assessed in vitro using immersion tests in simulated body fluid (SBF) at 37 ± 1 °C, evaluating mass loss, pH variation that occurred in the solution, open circuit potential (OCP), linear and cyclic potentiometry (LP and CP), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and nano-FTIR. To obtain plates as samples, the cast materials were thermo-mechanically processed by hot rolling. Dynamic mechanical analysis (DMA) was employed to evaluate the thermal properties of the smart material. Atomic force microscopy (AFM) was used to show the nanometric and microstructural changes during the hot rolling process and DMA solicitations. The type of corrosion identified was generalized corrosion, and over the first 3–5 days, an increase in mass was observed, caused by the compounds formed at the metal–solution interface. The formed compounds were identified mainly as oxides that passed into the immersion liquid. The degradation rate (DR) was obtained as a function of mass loss, sample surface area and immersion duration. The dynamic mechanical behavior and dimensions of the sample were evaluated after 14 days of immersion. The nanocompounds found on the surface after atmospheric corrosion and immersion in SBF were investigated with the Neaspec system using the nano-FTIR technique.

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Bioresorbability Dependence on Microstructure of Additivelly- Manufactured and Conventionally-Produced Fe-Mn Alloys

Godec,

Kraner,

Skobir Balantič

et al. 2024

Journal of Materials Research and Technology

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FeMn and FeMnAg biodegradable alloys: An in vitro and in vivo investigation

Cited by 7 publications

References 70 publications

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Investigations on the Degradation Behavior of Processed FeMnSi-xCu Shape Memory Alloys

Bioresorbability Dependence on Microstructure of Additivelly- Manufactured and Conventionally-Produced Fe-Mn Alloys

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