Femoral Neuropathy in Relation to Diabetes Mellitus: Report of 17 Cases

Goodman, Joseph I.

doi:10.2337/diab.3.4.266

Cited by 57 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hirson, Feinmann, and Wade (1953) also observed weakness and wasting of the quadriceps femoris muscle in 12 diabetics with neuropathy and commented on this being a most striking feature. Goodman (1954) presented 17 cases with femoral neuropathy, 16 of whom had diabetes mellitus, and suggested that the incidence of involvement of the femoral nerve in diabetes was higher than is generally realized. With control of the diabetes the condition reversed.…”

Section: Bruns (1890) First Drew Attention In Diabetics Tomentioning

confidence: 98%

Femoral nerve conduction in diabetes and chronic occlusive vascular disease.

Js¹,

Hurwitz²

1968

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

Section: Bruns (1890) First Drew Attention In Diabetics Tomentioning

confidence: 98%

Femoral nerve conduction in diabetes and chronic occlusive vascular disease.

Js¹,

Hurwitz²

1968

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

“…Later, Garland [20][21][22] employed the noncommittal title `diabetic amyotrophy', as it was not considered that the underlying pathology was satisfactorily established. Subsequently, electrodiagnostic [ 12,24,27] and neuropathological [32] studies demonstrated that the syndrome represents a proximal motor neuropathy, frequently referred to as diabetic femoral neuropathy [9,13,25]. The numerous more recent reports have been collected by Said and Thomas [34].…”

Section: Introductionmentioning

confidence: 99%

Epineurial microvasculitis in proximal diabetic neuropathy

1998

View full text Add to dashboard Cite

Amongst the focal and multifocal neuropathies that are associated with diabetes mellitus one of the most common is a proximal predominantly motor lower limb neuropathy. Recent evidence has indicated that, at least in a proportion of cases, this may have an inflammatory basis. We have examined a consecutive series of 15 cases of proximal diabetic neuropathy (diabetic amyotrophy). These were characterized by proximal pain and asymmetric proximal or generalized lower limb muscle weakness, associated in some cases with radicular sensory involvement. Two-thirds of the patients had an accompanying distal symmetric sensory polyneuropathy. Biopsy of the intermediate cutaneous nerve of the thigh, a sensory branch of the femoral nerve, showed epineurial microvasculitis in 3 patients and nonvasculitic epineurial inflammatory infiltrates in another case. In a further case, microvasculitis was found in both in the sural nerve and a quadriceps muscle biopsy specimen. The detection of inflammatory changes appeared to be correlated with the occurrence of sensory radicular involvement. Whether similar changes are present in muscle nerves in this predominantly motor syndrome requires further study. Nevertheless, the present observations confirm the view that secondary vasculitic or other inflammatory reactions may contribute to some forms of diabetic neuropathy.

show abstract

“…The patients included in this study, all with NIDDM of 10 to 28 years' duration, further illustrate the different patterns of proximal motor and sensory diabetic neuropathy [ I , [4][5][6][7][8][9][10]. It is well known that PDN can have a relapsing course and be part of a multifocal neuropathy, as in Patient 2 who first experienced, during a few weeks, a thoracic neuropathy, followed by a proximal, transient, sensorimotor involvement of the right side and then of the left side.…”

Section: Discussionmentioning

confidence: 99%

Painful proximal diabetic neuropathy: Inflammatory nerve lesions and spontaneous favorable outcome

Saïd¹,

Elgrably²,

Lacroix³

et al. 1997

Annals of Neurology

View full text Add to dashboard Cite

Proximal diabetic neuropathy is a disabling neuropathy that occurs predominantly in non-insulin-dependent diabetic patients over the age of 50. Inflammatory lesions have been found in nerve biopsy specimens of diabetic patients with severe proximal neuropathy or with other patterns of multifocal neuropathy. Some of these patients respond dramatically to treatment with corticosteroids or with other immunomodulators. In this article we report on our findings in 4 additional patients with painful proximal diabetic neuropathy and different patterns of inflammatory nerve lesions whose condition improved spontaneously shortly after performance of a nerve biopsy, without additional treatment.

show abstract

Femoral Neuropathy in Relation to Diabetes Mellitus: Report of 17 Cases

Cited by 57 publications

References 0 publications

Femoral nerve conduction in diabetes and chronic occlusive vascular disease.

Femoral nerve conduction in diabetes and chronic occlusive vascular disease.

Epineurial microvasculitis in proximal diabetic neuropathy

Painful proximal diabetic neuropathy: Inflammatory nerve lesions and spontaneous favorable outcome

Contact Info

Product

Resources

About