Femtosecond laser-induced periodic grooves and nanopore clusters make a synergistic effect on osteogenic differentiation

Xie, Haiqiong; Zhang, Chenke; Wang, Rui; Tang, Hong; Mu, Miduo; Li, Huaisheng; Guo, Yupeng; Yang, Liang; Tang, Kanglai

doi:10.1016/j.colsurfb.2021.112021

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…A femtosecond laser can be employed to induce periodic grooves on the surface of the PEEK implant, which improves the surface characteristics. Xie et al confirmed that the PEEK surface after exposure to a femtosecond laser showed increased adhesion, proliferation, and differentiation of mouse bone marrow mesenchymal stem cells (mBMSC) cells and increased expression and activity of alkaline phosphatase [ 48 ] ( Table 3 ). However, these findings will require substantiation with in vivo studies.…”

Section: Surface Treatmentsmentioning

confidence: 99%

Surface Treatments of PEEK for Osseointegration to Bone

2023

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Polymers, in general, and Poly (Ether-Ether-Ketone) (PEEK) have emerged as potential alternatives to conventional osseous implant biomaterials. Due to its distinct advantages over metallic implants, PEEK has been gaining increasing attention as a prime candidate for orthopaedic and dental implants. However, PEEK has a highly hydrophobic and bioinert surface that attenuates the differentiation and proliferation of osteoblasts and leads to implant failure. Several improvements have been made to the osseointegration potential of PEEK, which can be classified into three main categories: (1) surface functionalization with bioactive agents by physical or chemical means; (2) incorporation of bioactive materials either as surface coatings or as composites; and (3) construction of three-dimensionally porous structures on its surfaces. The physical treatments, such as plasma treatments of various elements, accelerated neutron beams, or conventional techniques like sandblasting and laser or ultraviolet radiation, change the micro-geometry of the implant surface. The chemical treatments change the surface composition of PEEK and should be titrated at the time of exposure. The implant surface can be incorporated with a bioactive material that should be selected following the desired use, loading condition, and antimicrobial load around the implant. For optimal results, a combination of the methods above is utilized to compensate for the limitations of individual methods. This review summarizes these methods and their combinations for optimizing the surface of PEEK for utilization as an implanted biomaterial.

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Section: Surface Treatmentsmentioning

confidence: 99%

Surface Treatments of PEEK for Osseointegration to Bone

2023

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“…In order to detect the release of SIM, the SCP/SIM/CPN specimen was submerged in PBS (4 mL) and laid in the shaking incubator at 37 °C. After culturing for the predetermined time (1,2,3,4,6,8,10,12,24,48,120,192,264,336, 504 h), PBS with SIM was gathered and then supplemented with an equal amount of fresh PBS. The release of SIM was examined using the UV−visible (UV−vis) spectrophotometer (UV, Shimadzu, Japan).…”

Section: In Vitro Degradation Testmentioning

confidence: 99%

Chemical Modification Strategy to Improve Biological Activity of Carbon Fiber-Reinforced Poly(ether ether ketone) Implants

Zhao

Dong

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Carbon fiber-reinforced poly(ether ether ketone) (CFRPEEK) composite materials, with good biocompatibility and human cortical bone-like elastic modulus, are considered as possible orthopedic implants. However, the inert surface caused inadequate osseointegration, which has limited the clinical application of CFRPEEK in the field of bone implants. To address this issue, a surface chemical modification strategy is proposed to construct a simvastatin (SIM) sustained-release system on the surface of CFRPEEK to promote angiogenesis and osteogenesis. Based on the Friedel–Crafts reaction between PEEK and succinic anhydride, carboxylated CFRPEEK is prepared to adsorb SIM through the surface pore structure, then chitosan/amino-terminated poly(ethylene glycol) (CS/PEG-NH2) (CPN) as a biocoating is covalently grafted on the surface to prevent the rapid diffusion of SIM (SCP/SIM/CPN). In vitro assays indicate that SCP/SIM/CPN exhibits the long-term sustained-release capability of SIM, good hydrophilicity, biomineralization capability, and excellent angiogenesis and bone regeneration/osseointegration. In addition, the rat subcutaneous implantation model confirms that surface modification improves the immunofluorescence intensity of VEGF and CD31 in the surrounding tissues of the implant by 1.65 and 1.60 times after 7 days of implantation, respectively. The rat cranial defect model further substantiates that, compared to the unmodified group, the bone mineral density and bone volume/total volume of the SCP/SIM/CPN group, respectively, increase by 1.84-fold and 1.58-fold after 12 weeks of implantation. This study has attempted to construct a drug sustained-release system on the surface of CFRPEEK by the chemical modification strategy to improve its osseointegration and angiogenesis features, and SCP/SIM/CPN as prepared has potential application in bone tissue engineering.

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“…The anisotropy of the surface structure including the interface of water droplets with micropores and ridges of grooves could prevent the surface liquid from diffusing, thereby leading to the contact angle values of FSL-etched PEEK being higher. H Xie et al 50 found that PEEK samples with surface grooves after FSL treatment resulted in the formation of a liquid-air interface on the surface, which resulted in the hydrophobicity of the samples. Compared with 0.3W-PEEK, the contact angle values of 0.5W-PEEK were slightly reduced.…”

Section: Surface Hydrophilicity and Surface Energymentioning

confidence: 99%