Femtosecond laser-made 3D micro-chainmail scaffolds towards regenerative medicine

Jonušauskas, Linas; Pautienius, Arnoldas; Ežerskytė, Eglė; Grigas, Juozas; Andriukaitis, Deividas; Gricius, Henrikas; Baravykas, Tomas; Andrijec, Dovilė; Vargalis, Rokas; Bandzevi̇či̇ūtė, Greta; Stankevi̇či̇us, Arūnas

doi:10.1016/j.optlastec.2023.109240

Cited by 3 publications

(1 citation statement)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result once again proves that hybrid organic-inorganic materials are very much bio-compatible and support cells even after they are physically manipulated. 22 Interestingly, in the case of the bigger scaffold, cells showed the tendency to also grow in the built-in channels. This was not ideal, as it meant that cells in the center of such organoid scaffold were also becoming necrotic.…”

Section: Rapid Printing Of Biomedical Structuresmentioning

confidence: 99%

Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

Jonušauskas,

Vitkūnaitė,

Andrijec

et al. 2024

Laser 3D Manufacturing XI

Self Cite

View full text Add to dashboard Cite

Two-photon polymerization (2PP) based 3D printing is a well-established technique. However, for the vast majority of its existence, 2PP was realized by applying general-purpose setups that were not tailored to any specific field. This resulted in limitations regarding how much 2PP can proliferate in any one particular area. Therefore, in this work, we will explore what can be achieved if a 2PP setup is built from the ground up for usage in one specific field -biomedical 3D printing. To achieve it a special femtosecond (fs) laser-based setup is assembled with integrated dynamic beam-shaping. Removal of zero order maximum in such an optical setup is demonstrated, and main related peculiarities are discussed. Then the beam-shaping is used to elongate voxels allowing to improve manufacturing throughput by more than two orders of magnitude. We then used the setup and developed voxel elongation methodology to produce biology-oriented structures, such as stents, grafts, and organoid scaffolds. We show excellent biocompatibility and cell growth on the later structures. Overall, the presented results show how focusing on 2PP system design to accommodate one particular field, in this case, biomedicine, helps to exploit the system's capabilities beyond what general purpose 2PP setup could achieve.

show abstract

Section: Rapid Printing Of Biomedical Structuresmentioning

confidence: 99%

Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

Jonušauskas,

Vitkūnaitė,

Andrijec

et al. 2024

Laser 3D Manufacturing XI

Self Cite

View full text Add to dashboard Cite

show abstract

3D Printed Edible Electronics: Components, Fabrication Approaches and Applications

Santhoshkumar,

Ramu,

Mahalakshmi

et al. 2024

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Femtosecond laser micro/nano processing: from fundamental to applications

Gao,

Zhang,

2024

Int. J. Extrem. Manuf.

View full text Add to dashboard Cite

Able to precise control and manipulate materials’ states at micro/nano-scale level, femtosecond laser micro/nano processing technology has underwent tremendous development over the past three decades. Free-forming three-dimensional microscale functional devices and inducing fascinating and unique physical or chemical phenomena have granted this technology with powerful versatility that no other technology can match. As this technology advances rapidly in various fields of application, some key challenges have emerged and remain to be urgently addressed. This review firstly introduces the fundamental principles for understanding how femtosecond laser pulses interact with materials and the associated unique phenomena in section 2. Then micro/nano-fabrication in transparent materials by femtosecond laser processing is presented in section 3. Thereafter, several high efficiency/throughput fabrication methods as well as pulse-shaping techniques are listed in section 4, and section 5 reviews four-dimensional and nanoscale printing realized by femtosecond laser processing technology. A special attention is paid to the heterogeneous integration of functional materials enabled by femtosecond laser processing in section 6. Several intriguing examples of three-dimensional functional micro-devices created by femtosecond laser based manufacturing methods such as microfluidics, lab-on-chip, micro-optics, micro-mechanics, micro-electronics, micro-bots and microbiodevices are reviewed in section 7. Finally, a summary of the review and a perspective are proposed to explore the challenges and future opportunities for further betterment of femtosecond laser micro/nano processing technology.

show abstract

Femtosecond laser-made 3D micro-chainmail scaffolds towards regenerative medicine

Cited by 3 publications

References 82 publications

Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

3D Printed Edible Electronics: Components, Fabrication Approaches and Applications

Femtosecond laser micro/nano processing: from fundamental to applications

Contact Info

Product

Resources

About