Femtosecond laser pulse filamentation versus optical breakdown in H 2 O

Liu, Weiwei; Kosareva, O.G.; Golubtsov, I.S.; Iwasaki, Atsushi; Becker, Andreas; Kandidov, V.P.; Chin, See Leang

doi:10.1007/s00340-002-1087-1

Cited by 170 publications

(110 citation statements)

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“…As shown in previous studies, [32][33][34] when the pumping laser wavelength is relatively far from the absorption band of Au nanoparticles (depending on nanoparticle size), the nanoparticles are predominantly ablated by radiation from a white light supercontinuum (presenting a wide spectrum from ultraviolet [UV] to infrared of femtosecond pulse length), generated in the water environment due to nonlinear self-focusing effects that normally accompany femtosecond laser-liquid interaction. 37 In our experiments, this white light supercontinuum was clearly visible in the liquid volume. The femtosecond-laser fragmentation process led to a change of solution color into deep (dark) red without any sign of yellow tints.…”

Section: Synthesis Of Au Nanoparticlessupporting

confidence: 54%

Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation

Kubiliūtė¹,

Maximova²,

Lajevardipour³

et al. 2013

IJN

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Aqueous solutions of ultra-pure gold nanoparticles have been prepared by methods of femtosecond laser ablation from a solid target and fragmentation from already formed colloids. Despite the absence of protecting ligands, the solutions could be (1) fairly stable and poly size-dispersed; or (2) very stable and monodispersed, for the two fabrication modalities, respectively. Fluorescence quenching behavior and its intricacies were revealed by fluorescence lifetime imaging microscopy in rhodamine 6G water solution. We show that surface-enhanced Raman scattering of rhodamine 6G on gold nanoparticles can be detected with high fidelity down to micromolar concentrations using the nanoparticles. Application potential of pure gold nanoparticles with polydispersed and nearly monodispersed size distributions are discussed.

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Section: Synthesis Of Au Nanoparticlessupporting

confidence: 54%

Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation

Kubiliūtė¹,

Maximova²,

Lajevardipour³

et al. 2013

IJN

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“…So, with these irradiation parameters, we can confirm theoretically the occurrence of the filamentation process in the cuvette by evaluating the starting point of filaments in water (50). If one takes into account that we approximate our incident beam by a Gaussian parallel beam with a radius at the 1∕e 2 level of the beam profile equals to wðzÞ, it will self-focus in the cuvette after the empirical distance z f :…”

Section: Methodsmentioning

confidence: 96%

“…For a 3.5-GW laser pulse, the intensity inside the sample container due to the geometrical focus reaches values between 2.1 × 10 11 W·cm −2 and 3 × 10 11 W·cm −2 . According to (50), the optical breakdown threshold of water for our laser pulses is close to 5.6 × 10 12 W·cm −2 . Thus, our irradiation parameters avoid in theory the generation of hot high-density plasmas in aqueous solutions.…”

Section: Methodsmentioning

confidence: 99%

Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose

Meesat

Belmouaddine

Allard

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Since the invention of cancer radiotherapy, its primary goal has been to maximize lethal radiation doses to the tumor volume while keeping the dose to surrounding healthy tissues at zero. Sadly, conventional radiation sources (γ or X rays, electrons) used for decades, including multiple or modulated beams, inevitably deposit the majority of their dose in front or behind the tumor, thus damaging healthy tissue and causing secondary cancers years after treatment. Even the most recent pioneering advances in costly proton or carbon ion therapies can not completely avoid dose buildup in front of the tumor volume. Here we show that this ultimate goal of radiotherapy is yet within our reach: Using intense ultra-short infrared laser pulses we can now deposit a very large energy dose at unprecedented microscopic dose rates (up to 1011 Gy/s) deep inside an adjustable, well-controlled macroscopic volume, without any dose deposit in front or behind the target volume. Our infrared laser pulses produce high density avalanches of low energy electrons via laser filamentation, a phenomenon that results in a spatial energy density and temporal dose rate that both exceed by orders of magnitude any values previously reported even for the most intense clinical radiotherapy systems. Moreover, we show that (i) the type of final damage and its mechanisms in aqueous media, at the molecular and biomolecular level, is comparable to that of conventional ionizing radiation, and (ii) at the tumor tissue level in an animal cancer model, the laser irradiation method shows clear therapeutic benefits.

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“…In order to obtain the sample of Au-NPs in pure deionized water (Au-NPw) with narrow size distribution, the NPs produced by laser ablation underwent the laser fragmentation step as it was described before. 30,43 Briefly, 5 mL of the previously prepared solution was placed in a glass cuvette and was irradiated for 30 minutes by an fs laser beam of a Yb:KGW laser, focused in the very middle of the cuvette, using the same focusing lens. The energy of the laser beam was varied from 10 μJ to 100 μJ in order to get the NPs with different mean sizes and narrow size distribution.…”

Section: Au-np Solutionsmentioning

confidence: 99%

Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

Correard¹,

Maximova²,

Estève³

et al. 2014

IJN

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Due to excellent biocompatibility, chemical stability, and promising optical properties, gold nanoparticles (Au-NPs) are the focus of research and applications in nanomedicine. Au-NPs prepared by laser ablation in aqueous biocompatible solutions present an essentially novel object that is unique in avoiding any residual toxic contaminant. This paper is conceived as the next step in development of laser-ablated Au-NPs for future in vivo applications. The aim of the study was to assess the safety, uptake, and biological behavior of laser-synthesized Au-NPs prepared in water or polymer solutions in human cell lines. Our results showed that laser ablation allows the obtaining of stable and monodisperse Au-NPs in water, polyethylene glycol, and dextran solutions. The three types of Au-NPs were internalized in human cell lines, as shown by transmission electron microscopy. Biocompatibility and safety of Au-NPs were demonstrated by analyzing cell survival and cell morphology. Furthermore, incubation of the three Au-NPs in serum-containing culture medium modified their physicochemical characteristics, such as the size and the charge. The composition of the protein corona adsorbed on Au-NPs was investigated by mass spectrometry. Regarding composition of complement C3 proteins and apolipoproteins, Au-NPs prepared in dextran solution appeared as a promising drug carrier. Altogether, our results revealed the safety of laser-ablated Au-NPs in human cell lines and support their use for theranostic applications.

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Femtosecond laser pulse filamentation versus optical breakdown in H 2 O

Cited by 170 publications

References 0 publications

Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation

Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation

Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose

Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

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