FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness

Peng, Zhenxiang; Wang, Shuling; Wen, Diguang; Mei, Zhechuan; Zhang, Hao; Liao, Shengtao; Lv, Lin; Li, Chuanfei

doi:10.1016/j.tranon.2024.101916

Cited by 3 publications

(2 citation statements)

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“…The observation that FEN1 expression is higher in the early stages of tumor cell development suggests a role in the initial phases of tumorigenesis or in maintaining a stem-like state of the tumor cells. This finding is supported by research from Z. Peng, et al., which confirmed FEN1’s capability to promote stemness in tumor cells ( 80 ).…”

Section: Discussionsupporting

confidence: 62%

A mitochondria-related genes associated neuroblastoma signature - based on bulk and single-cell transcriptome sequencing data analysis, and experimental validation

Wang,

Tan,

Jin

et al. 2024

Front. Immunol.

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BackgroundNeuroblastoma (NB), characterized by its marked heterogeneity, is the most common extracranial solid tumor in children. The status and functionality of mitochondria are crucial in regulating NB cell behavior. While the significance of mitochondria-related genes (MRGs) in NB is still missing in key knowledge.Materials and methodsThis study leverages consensus clustering and machine learning algorithms to construct and validate an MRGs-related signature in NB. Single-cell data analysis and experimental validation were employed to characterize the pivotal role of FEN1 within NB cells.ResultsMRGs facilitated the classification of NB patients into 2 distinct clusters with considerable differences. The constructed MRGs-related signature and its quantitative indicators, mtScore and mtRisk, effectively characterize the MRGs-related patient clusters. Notably, the MRGs-related signature outperformed MYCN in predicting NB patient prognosis and was adept at representing the tumor microenvironment (TME), tumor cell stemness, and sensitivity to the chemotherapeutic agents Cisplatin, Topotecan, and Irinotecan. FEN1, identified as the most contributory gene within the MRGs-related signature, was found to play a crucial role in the communication between NB cells and the TME, and in the developmental trajectory of NB cells. Experimental validations confirmed FEN1’s significant influence on NB cell proliferation, apoptosis, cell cycle, and invasiveness.ConclusionThe MRGs-related signature developed in this study offers a novel predictive tool for assessing NB patient prognosis, immune infiltration, stemness, and chemotherapeutic sensitivity. Our findings unveil the critical function of FEN1 in NB, suggesting its potential as a therapeutic target.

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Section: Discussionsupporting

confidence: 62%

A mitochondria-related genes associated neuroblastoma signature - based on bulk and single-cell transcriptome sequencing data analysis, and experimental validation

Wang,

Tan,

Jin

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The observation that FEN1 expression is higher in the early stages of tumor cell development suggests a role in the initial phases of tumorigenesis or in maintaining a stem-like state of the tumor cells. This finding is supported by research from Z. Peng, et al, which confirmed FEN1's capability to promote stemness in tumor cells (80).…”

Section: Discussionsupporting

confidence: 61%