Fenofibrate protects the neurovascular unit and ameliorates plasma corticosterone levels in pentylenetetrazole-induced kindling seizure in mice

Cardiovascular therapeutics: A new potential for anxiety treatment?

“…On the contrary, statin's pleiotropic effects including antiproliferation, antioxidation, and anti-inflammation 256 could underlie some protective findings in terms of anxiety mitigation demonstrated in experimental settings [138][139][140][141][142] ; the same can be valid for fenofibrate's anxiolytic effects. [151][152][153] Although ivabradine's protection in HF patients is restricted, 277 it could be beneficial in several off-labeled indications due to its various pleiotropic actions. 284 No disturbing effects of ivabradine on anxiety were observed in animal experiments, 155,156 while in patients with CVDs, ivabradine administration was even associated with improved quality of life.…”

“…Another potentially harmful condition could be statin‐induced CoQ‐10 depletion associated with anaerobic metabolism, mitochondrial bioenergetic impairment, 313 and increased oxidizability of LDL cholesterol, 314 which might induce ischemia and functional alterations in CNS. On the contrary, statin's pleiotropic effects including antiproliferation, antioxidation, and anti‐inflammation 256 could underlie some protective findings in terms of anxiety mitigation demonstrated in experimental settings 138–142 ; the same can be valid for fenofibrate's anxiolytic effects 151–153 …”

“…In the pentylenetetrazol‐induced kindling seizure model in mice, the fenofibrate treatment increased the time spent in the open arms and the percentage of open arm entries in the EPM. 151 Fenofibrate in autism spectrum disorder in rats increased the percentage of time spent in and number of entries to the open arm in the EPM. 152 , 153 It seems that this anxiolytic property of fenofibrate includes antioxidative, anti‐inflammatory, 153 and neurosteroidogenic effects through PPARα activation in the brain 154 (Table 1 ).…”

“…In the pentylenetetrazol‐induced kindling seizure model in mice, the fenofibrate treatment increased the time spent in the open arms and the percentage of open arm entries in the EPM 151 . Fenofibrate in autism spectrum disorder in rats increased the percentage of time spent in and number of entries to the open arm in the EPM 152,153 .…”

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

“…The desired arylated products were successfully obtained in moderate to good yields (Scheme 56A and B). Amongst the obtained products, two were derived from the commercially available drugs clofibrate ( 176) [265] (trade name Atromid-S ® ) and fenofibrate (177) [266] (marketed under the name TriCor ® ), used to treat abnormal blood lipid levels (Scheme 56C).…”