Fenoldopam Reduces the Need for Renal Replacement Therapy and In-Hospital Death in Cardiovascular Surgery: A Meta-Analysis

Landoni, Giovanni; Biondi‐Zoccai, Giuseppe; Marino, Giovanni; Bove, Tiziana; Fochi, Oliviero; Maj, Giulia; Calabrò, Maria Grazia; Sheiban, Imad; Tumlin, James A.; Ranucci, Marco; Zangrillo, Alberto

doi:10.1053/j.jvca.2007.07.015

Cited by 141 publications

(53 citation statements)

References 31 publications

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“…The benefit of fenoldopam in terms of AKI occurrence is difficult to evaluate due to heterogenous delays in administration and diagnosis criteria among studies. Four meta-analyses are available but show conflicting results: two of them reported a beneficial effect with a reduction in the risk of AKI, one did not find any beneficial effect and the last one did not analyse the risk of AKI [181][182][183][184]. Considering current data in the literature, it is recommended not to use fenoldopam for the prevention or treatment of AKI.…”

Section: Rationalementioning

confidence: 99%

Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)

Ichai

Vinsonneau

Souweine

et al. 2016

Anaesthesia Critical Care & Pain Medicine

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Acute kidney injury (AKI) is a syndrome that has progressed a great deal over the last 20 years. The decrease in urine output and the increase in classical renal biomarkers, such as blood urea nitrogen and serum creatinine, have largely been used as surrogate markers for decreased glomerular filtration rate (GFR), which defines AKI. However, using such markers of GFR as criteria for diagnosing AKI has several limits including the difficult diagnosis of non-organic AKI, also called "functional renal insufficiency" or "pre-renal insufficiency". This situation is characterized by an oliguria and an increase in creatininemia as a consequence of a reduction in renal blood flow related to systemic haemodynamic abnormalities. In this situation, "renal insufficiency" seems rather inappropriate as kidney function is not impaired. On the contrary, the kidney delivers an appropriate response aiming to recover optimal systemic physiological haemodynamic conditions. Considering the kidney as insufficient is erroneous because this suggests that it does not work correctly, whereas the opposite is occurring, because the kidney is healthy even in a threatening situation. With current definitions of AKI, normalization of volaemia is needed before defining AKI in order to avoid this pitfall.

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Section: Rationalementioning

confidence: 99%

Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)

Ichai

Vinsonneau

Souweine

et al. 2016

Anaesthesia Critical Care & Pain Medicine

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“…8,9 Fenoldopam is a DA1 selective agonist, slightly more potent than dopamine but deprived of any effects in other receptors. 10 Unlike other dopaminergic agents, fenoldopam is a selective DA1 receptor agonist that continues to have vasodilatory properties at higher doses.…”

Section: Discussionmentioning

confidence: 99%

Retracted Fenoldopam in critically ill patients with early renal dysfunction: A crossover study

Paparcuri¹,

Cobas²,

Pena³

et al. 2011

Dialysis & Transplantation

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Retraction: The following article from Dialysis & Transplantation, 'Fenoldopam in critically ill patients with early renal dysfunction: A crossover study' by Gian Paparcuri, Miguel Cobas, Maria De La Pena, Erik Barquist and Albert Varon, published online on March 8, 2011 in Wiley Online Library (wileyonlinelibrary.com), and in Volume 40, pp. 164‐167, has been retracted through agreement between the first author, the Editors, Andrew Z. Fenves and Larry B. Melton, and Wiley Periodicals, Inc. The retraction has been agreed due to duplicate publication in another journal.

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“…Nieco bardziej zachęcająco brzmią informacje o korzyściach płynących z zastosowania fenoldopamu. Choć kompilacja dostępnych danych nie przemawia za jego szerokim stosowaniem [10], głównie z uwagi na niedostateczną liczbę danych pochodzących z dużych randomizowanych badań klinicznych, to metaanaliza 13 dotychczas opublikowanych prac randomizowanych i nierandomizowanych pokazuje, że zastosowanie fenoldopamu u chorych poddawanych operacjom kardiochirurgicznym pozwala ograniczyć konieczność leczenia nerkozastępczego o 63% oraz zmniejszyć ryzyko wczesnego zgonu o 46% [50]. Również w randomizowanym badaniu przeprowadzonym przez Morelli i wsp.…”

Section: Metody Farmakologiczneunclassified

Postępowanie w okresie okołooperacyjnym u chorych z ryzykiem wystąpienia ostrego uszkodzenia nerek, poddawanych operacjom kardiochirurgicznym

Krzych

Wybraniec²,

Chudek³

et al. 2013

Anaesthesiol Intensive Ther

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Acute kidney injury is one of the most frequent and clinically important of all postoperative complications in cardiac surgery. It is estimated that almost half of subjects suffer from a deterioration of kidney function after a cardio-pulmonary by-pass. Renal insufficiency impacts upon the outcome in terms of an increase in postoperative morbidity and mortality, and a decrease in quality of life. Recently, a modified and unified classification of cardio-renal syndrome has been devised, which takes into account bilateral association between the heart and the kidneys. Because acute decompensation in heart function leads to acute kidney damage, therefore cardiac surgery-associated acute kidney injury may be recognised as a type 1 cardio-renal syndrome from a pathophysiological point of view. This paper aims to review the current data on the diagnosis of acute kidney injury and preventive strategies that can be implemented in cardiac surgery perioperative care.

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Fenoldopam Reduces the Need for Renal Replacement Therapy and In-Hospital Death in Cardiovascular Surgery: A Meta-Analysis

Cited by 141 publications

References 31 publications

Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)

Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)

Retracted Fenoldopam in critically ill patients with early renal dysfunction: A crossover study

Postępowanie w okresie okołooperacyjnym u chorych z ryzykiem wystąpienia ostrego uszkodzenia nerek, poddawanych operacjom kardiochirurgicznym

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