Fenótipo da gordura, fatores associados e o polimorfismo rs9939609 do gene FTO DOI:10.5007/1980-0037.2010v12n2p164

Lima, William Alves; Glaner, Maria Fátima; Taylor, Aline Pic

doi:10.5007/1980-0037.2010v12n2p164

Cited by 10 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity is a multifactorial condition with a strong lifestyle-allied influence. It is determined by environmental as well as genetic factors, triggering several other diseases [25] [28] [29]. Familial history has been identified as a chief risk factor for several chronic diseases of public health significance, including obesity.…”

Section: Discussionmentioning

confidence: 99%

Familial Background as a Hidden Cause for Obesity among College Going Girls

Mangla¹,

Dhamija²,

Gupta³

et al. 2019

JBM

View full text Add to dashboard Cite

Background: Rapid changes in global economies and industrialization have resulted in switch from traditional diets and labor intensive lifestyle to consumption of modern calorie-rich diets loaded with fat and sugar contents, accompanied with sedentary lifestyle further leading to onset of numerous non-communicable, chronic disorders; obesity being one of them. This study aims at investigating risk posed by family history of obesity over the generations for inducing extreme overweight conditions among adolescent females of Delhi. Methods: Present work is a cross-sectional study conducted in Delhi (India) with sample size of 444 females aged between 18-22 years. Socio-demographic aspect along with lifestyle-related profile of participants was assessed using a self-administered proforma. Prior history of obesity among family members, if any, was noted as well, and anthropometric and physiologic measurements were recorded using well established customary techniques. Analysis was carried out in SPSS 20.0. Results: Participants holding a history for obesity in family were comparatively more obese than their counterparts. Positive family history for the same has been found possessing a notably closer association with elevated levels of adiposity determined by various physical and physiological variables. Conclusion: Family history of excessive fatness develops high risk of pathological manifestation for the same in upcoming generations that needs to be administered effectively-at individual or population level, and addressed efficiently by one's family or by the prevailing governmental provisions.

show abstract

Section: Discussionmentioning

confidence: 99%

Familial Background as a Hidden Cause for Obesity among College Going Girls

Mangla¹,

Dhamija²,

Gupta³

et al. 2019

JBM

View full text Add to dashboard Cite

show abstract

“…In fact, FTO is a highly polymorphic gene located on chromosome 16q12.2, and several of its variants have been associated with energy regulation and body mass index (BMI) [10][11][12][13][14]. Among the polymorphisms, rs9939609 has been the most thoroughly studied and annotated to be associated with the obesity phenotype [15,16]. Additionally, ghrelin, a peptide produced in the stomach, has important roles in growth hormone secretion, appetite stimulation, food intake, regulation of gastric motility and acid secretion, adiposity, energy homeostasis and inflammatory processes [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms and increased DNA damage in morbidly obese women

Luperini

Almeida

Porto

et al. 2015

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

View full text Add to dashboard Cite

“…The mechanisms that explain why the polymorphisms of the rs9939609 of the FTO gene influence in the accumulation of body adiposity have not yet been elucidated 27 . However, Benedict et al 28 found that FTO may facilitate weight gain by increasing grelin (hunger hormone) and decreasing leptine (saciety hormone) plasma levels.…”

Section: Discussionmentioning

confidence: 99%

FTO gene variant and association with overweight in Brazilian male students

Moraes

Laitano

Sales

et al. 2016

Rev. Bras. Cineantropom. Desempenho Hum.

View full text Add to dashboard Cite

-Obesity is considered a disease with multiple etiologies. Recent advances in technology have pointed candidate genes that are related to weight gain in several populations. However, in countries with ethnic miscegenation, such as Brazil, studies of this nature with students are still scarce. The aim of the present study was to compare anthropometric variables of Brazilian male students according to the genotypes of the rs9939609 of the FTO gene. In order to do so, 205 participants underwent body mass, height, waist circumference and skinfold thickness measurements. Body mass index (BMI), waist-to-height ratio and body fat percentage were calculated. Volunteers were characterized as overweight according to the BMI-for-age z-score. Participants were genotyped according to the single nucleotide polymorphism rs9939609 of the FTO gene (AA, AT and TT). ANOVA one-way with Bonferroni's post hoc was performed to compare genotypes and anthropometric variables. Odds Ratio was calculated to reveal increased chances of presenting higher body mass index z-score, waist-to-height ratio and body fat percentage. Participants homozygous for the A allele presented significantly higher values of BMI-for-age z-score (0.38±1.01 vs. -0.29±1.15), waist circumference (77.15±6.51 vs. 72.85±7.36 cm) and waist-to-height ratio (0.44±0.04 vs. 0.42±0.04) when compared to individuals with the TT genotype. The A allele of the rs9939609 of the FTO gene seems to influence in the adiposity of male students. (0,38±1,01 vs. -0,29±1,15), circunferência da cintura (77,15±6,51 vs. 72,85±7,36 cm) e relação cintura-estatura (0,44±0,04 vs. 0,42±0,04)

show abstract

Fenótipo da gordura, fatores associados e o polimorfismo rs9939609 do gene FTO DOI:10.5007/1980-0037.2010v12n2p164

Cited by 10 publications

References 28 publications

Familial Background as a Hidden Cause for Obesity among College Going Girls

Familial Background as a Hidden Cause for Obesity among College Going Girls

Gene polymorphisms and increased DNA damage in morbidly obese women

FTO gene variant and association with overweight in Brazilian male students

Contact Info

Product

Resources

About