Fentanyl and naloxone effects on glutamate and GABA release rates from anterior hypothalamus in freely moving rats

Pourzitaki, Chryssa; Tsaousi, Georgia; Papazisis, Georgios; Kyrgidis, Athanassios; Zacharis, Constantinos K.; Κritis, Aristeidis; Malliou, Foteini; Kouvelas, Dimitrios

doi:10.1016/j.ejphar.2018.07.029

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…We hypothesized that the isoflurane MAC‐sparing effects observed with some phenylpiperidine opioids might be mediated by nonopioid receptor effects. Fentanyl decreases neuronal release of acetylcholine to reduce muscarinic cholinergic activity (Mortazavi, Thompson, Baghdoyan, & Lydic, 1999), decreases release of glutamate that may reduce excitatory NMDA receptor currents, and increases release of γ‐aminobutyric acid (GABA) that may enhance inhibitory GABA A receptor currents (Pourzitaki et al., 2018). Additionally, various opioids at sufficient concentrations can directly modulate NMDA receptors (Hahnenkamp et al., 2004), α 1 ‐adrenergic receptors (Toda & Hatano, 1977), α 2 ‐adrenergic receptors (Hocker et al., 2008, 2009), dopamine receptors (Hagelberg et al., 2002), serotonin receptors (Leysen & Gommeren, 1986), voltage‐gated sodium channels (Leffler et al., 2012), and potassium channels (Tschirhart, Li, Guo, & Zhang, 2019).…”

Section: Introductionmentioning

confidence: 99%

Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats

Brosnan

Pypendop

Stanley

2020

Vet Pharm & Therapeutics

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Different structurally related phenylpiperidine opioids exhibit different isoflurane‐sparing effects in cats. Because minimum alveolar concentration (MAC) in cats is affected only by very high plasma concentrations of some phenylpiperidine opioids, we hypothesized these effects are caused by actions on nonopioid receptors. Using a prospective, randomized, crossover design, six cats were anesthetized with isoflurane, intubated, ventilated, and instrumented. Isoflurane MAC was measured in triplicate using a tail‐clamp and bracketing technique. A computer‐controlled intravenous infusion using prior pharmacokinetic models targeted plasma concentrations of 60 ng/ml fentanyl, 10 ng/ml sufentanil, or 500 ng/ml alfentanil, and isoflurane MAC was measured in duplicate. Next, naltrexone 0.6 mg/kg was administered to cats hourly during the opioid infusion, and isoflurane MAC was measured in duplicate. Blood was collected during MAC determinations to measure opioid concentrations. Responses were analyzed using repeated measures ANOVA with significance at p < .05. Alfentanil and sufentanil decreased isoflurane MAC by 16.4% and 6.4%, respectively, and these effects were completely reversed by naltrexone. Fentanyl had no significant effect on isoflurane MAC. Alfentanil and sufentanil modestly reduce isoflurane MAC via agonist effects on opioid receptors. However, these effects are too small to justify clinical use of phenylpiperidine opioids as single agents to reduce MAC in cats.

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Section: Introductionmentioning

confidence: 99%

Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats

Brosnan

Pypendop

Stanley

2020

Vet Pharm & Therapeutics

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“…Nitrous oxide was also used in cats, which inhibits N -methyl-D-aspartate channels [31]. Opioids, such as sufentanil, generate increases in GABA release, amongst other effects [32]. In general, the enhancement of GABA is similar between anaesthetics but they may differ enough in detail to influence the percentage of contrast-dependent phase-sensitive cells in V1.…”

Section: Discussionmentioning

confidence: 99%

Comparison of contrast-dependent phase sensitivity in primary visual cortex of mouse, cat and macaque

2019

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Neurones in the primary visual cortex (V1) are classified into simple and complex types. Simple cells are phase-sensitive, that is, they modulate their responses according to the position and brightness polarity of edges in their receptive fields. Complex cells are phase invariant, that is, they respond to edges in their receptive fields regardless of location or brightness polarity. Simple and complex cells are quantified by the degree of sensitivity to the spatial phases of drifting sinusoidal gratings. Some V1 complex cells become more phase-sensitive at low contrasts. Here we use a standardized analysis method for data derived from grating stimuli developed for macaques to reanalyse data previously collected from cats, and also collect and analyse the responses of 73 mouse V1 neurons. The analysis provides the first consistent comparative study of contrast-dependent phase sensitivity in V1 of mouse, cat and macaque monkey.

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“…A study on neurotransmitter release rate in the hypothalamus found that rats treated with fentanyl for 75 min had slower glutamate and faster GABA release. However, no comment was made on total metabolite levels [ 152 ]. Rapidly proliferating cancer cells depend on glutamine uptake for anapleorosis into the TCA cycle to eventually produce ATP, NADH, and FADH 2 .…”

Section: Glutamine Metabolismmentioning

confidence: 99%

Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer

Tarazi,

Maynes

2023

Pharmaceutics

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Opioid utilization for pain management is prevalent among cancer patients. There is significant evidence describing the many effects of opioids on cancer development. Despite the pivotal role of metabolic reprogramming in facilitating cancer growth and metastasis, the specific impact of opioids on crucial oncogenic metabolic pathways remains inadequately investigated. This review provides an understanding of the current research on opioid-mediated changes to cellular metabolic pathways crucial for oncogenesis, including glycolysis, the tricarboxylic acid cycle, glutaminolysis, and oxidative phosphorylation (OXPHOS). The existing literature suggests that opioids affect energy production pathways via increasing intracellular glucose levels, increasing the production of lactic acid, and reducing ATP levels through impediment of OXPHOS. Opioids modulate pathways involved in redox balance which may allow cancer cells to overcome ROS-mediated apoptotic signaling. The majority of studies have been conducted in healthy tissue with a predominant focus on neuronal cells. To comprehensively understand the impact of opioids on metabolic pathways critical to cancer progression, research must extend beyond healthy tissue and encompass patient-derived cancer tissue, allowing for a better understanding in the context of the metabolic reprogramming already undergone by cancer cells. The current literature is limited by a lack of direct experimentation exploring opioid-induced changes to cancer metabolism as they relate to tumor growth and patient outcome.

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Fentanyl and naloxone effects on glutamate and GABA release rates from anterior hypothalamus in freely moving rats

Cited by 8 publications

References 46 publications

Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats

Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats

Comparison of contrast-dependent phase sensitivity in primary visual cortex of mouse, cat and macaque

Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer

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