Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice

Rademeyer, Kara M.; R. Nass, Sara; Jones, Austin M.; Ohene-Nyako, Michael; Hauser, Kurt F.; McRae, MaryPeace

doi:10.1007/s13365-023-01186-4

J. Neurovirol.

2024

DOI: 10.1007/s13365-023-01186-4

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Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice

Kara M. Rademeyer,

Sara R. Nass,

Austin M. Jones

et al.

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Cited by 4 publications

References 193 publications

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The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

Nozohouri,

Ahn,

Zoubi

et al. 2024

Pharm Res

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The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

Nozohouri,

Ahn,

Zoubi

et al. 2024

Pharm Res

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Something to talk about; crosstalk disruption at the neurovascular unit during HIV infection of the CNS

Galpayage Dona,

Benmassaoud,

Gipson

et al. 2024

NeuroImmune Pharmacology and Therapeutics

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Although treatable with antiretroviral therapy, HIV infection persists in people living with HIV (PLWH). It is well known that the HIV virus finds refuge in places for which antiretroviral medications do not reach therapeutic levels, mainly the CNS. It is clear that as PLWH age, the likelihood of developing HIV-associated neurological deficits increases. At the biochemical level neurological dysfunction is the manifestation of altered cellular function and ineffective intercellular communication. In this review, we examine how intercellular signaling in the brain is disrupted in the context of HIV. Specifically, the concept of how the blood-brain barrier can be a convergence point for crosstalk, is explored. Crosstalk between the cells of the neurovascular unit (NVU) (endothelium, pericytes, astrocytes, microglia and neurons) is critical for maintaining proper brain function. In fact, the NVU allows for rapid matching of neuronal metabolic needs, regulation of blood-brain barrier (BBB) dynamics for nutrient transport and changes to the level of immunosurveillance. This review invites the reader to conceptually consider the BBB as a router or convergence point for NVU crosstalk, to facilitate a better understanding of the intricate signaling events that underpin the function of the NVU during HIV associated neuropathology.

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Structural and Functional Dysregulation of the Brain Endothelium in HIV Infection and Substance Abuse

Annadurai,

Kanmogne

2024

Cells

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Blood–brain barrier (BBB) injury and dysfunction following infection with the human immunodeficiency virus (HIV) enables viral entry into the brain, infection of resident brain cells, neuronal injury and subsequent neurodegeneration leading to HIV-associated neurocognitive disorders (HAND). Although combination antiretroviral therapy has significantly reduced the incidence and prevalence of acquired immunodeficiency syndrome and increased the life expectancy of people living with HIV, the prevalence of HAND remains high. With aging of people living with HIV associated with increased comorbidities, the prevalence of HIV-related central nervous system (CNS) complications is expected to remain high. Considering the principal role of the brain endothelium in HIV infection of the CNS and HAND, the purpose of this manuscript is to review the current literature on the pathobiology of the brain endothelium structural and functional dysregulation in HIV infection, including in the presence of HIV-1 and viral proteins (gp120, Tat, Nef, and Vpr). We summarize evidence from human and animal studies, in vitro studies, and associated mechanisms. We further summarize evidence of synergy or lack thereof between commonly abused substances (cocaine, methamphetamine, alcohol, tobacco, opioids, and cannabinoids) and HIV- or viral protein-induced BBB injury and dysfunction.

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Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice

Cited by 4 publications

References 193 publications

The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

Something to talk about; crosstalk disruption at the neurovascular unit during HIV infection of the CNS

Structural and Functional Dysregulation of the Brain Endothelium in HIV Infection and Substance Abuse

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