Fentanyl Exerts an Antitumor Effect on Papillary Thyroid Cancer by Regulating the miR-204/KLF5 Axis

Sufficient propofol or fentanyl doses necessary to prevent the response to skin incision do not necessarily reduce hemodynamic responses during surgery. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and fentanyl with respect to the sedative effects and safety during painless gastrointestinal endoscopy. From October 2018 to October 2020, 200 patients undergoing painless gastrointestinal endoscopy in our department’s outpatient or inpatient clinic were selected and randomly divided into a control group and an observation group, 100 patients per group. Prior to surgery, the patients in the two groups were required to be connected to an electrocardiogram monitor and then were instructed to lie on the left side and receive continuous oxygen infusion of 2-3 L/min with a nasal cannula. The control group was injected with propofol injection (100 mg/min). The observation group was given fentanyl intravenous injection at a dose of 0.1 μg/kg followed by propofol injection (100 mg/min). Painless gastrointestinal endoscopy was performed after the patients entered a sleep state and the eyelash reaction disappeared. Outcome analysis was performed on preoperative and intraoperative hemodynamic indicators, including heart rate, blood oxygen saturation, dose of propofol, time for endoscopy, recovery time, hospitalization after recovery, Montreal Cognitive Assessment (MoCA) score, and Mini-Mental State Examination (MMSE) score. The incidence rate of adverse reactions in the observation group was 6%, which was notably lower than that of the control group (18%). The total response rate of the observation group was 98%, which was significantly higher than that of the control group (90%) ( P < 0.05 ). The intraoperative heart rate and blood oxygen saturation of the observation group were higher than those of the control group ( P < 0.0 ss ). The patients receiving sedation with propofol plus fentanyl had fewer doses of propofol and shorter recovery time than those receiving propofol alone ( P < 0.05 ). It was also revealed that the patients receiving sedation with propofol plus fentanyl exhibited more MoCA and MMSE scores than those receiving propofol alone 30 min after sedation during painless gastrointestinal endoscopy. Taken together, sedation with propofol combined with fentanyl was more effective and safer than that with propofol alone in painless gastrointestinal endoscopy, which can ensure a wake-up state, stable breathing cycle, and better gastrointestinal painless procedure.

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Vanadium dioxide based terahertz dual-frequency multi-function coding metasurface

Jing-Li¹,

Dong²,

Liang³

et al. 2023

Acta Phys. Sin.

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Terahertz (THz) wave has the advantages of low photon energy, high resolution, large communication bandwidth, etc. It has broad application prospects in security detection, high-resolution imaging, high-speed communication and other fields. In recent years, as a new way to control THz wave, THz metasurface functional devices have attracted extensive attention of researchers. In this paper, vanadium dioxide (VO2), a phase change material, is introduced into the coding metasurface. By regulating a circularly polarized wave and the orthogonal linearly polarized waves independently, a multi-function coding metasurface that can work at dual frequency points is obtained. It is composed of three layers. The top layeris a metal-VO2 composite structure. The middle is a polyimide dielectric layer. The bottom is a metal ground. Under certain conditions, the double split ring resonator (DSRR) and the cross structure in the top layer are relatively independent. Designing the coding sequences for them separately can enable the coding metasurface to have multiple functions. The electromagnetic simulation software CST is used for modeling and simulation, and the results are as follows. When the VO2 is in an insulating state and a circularly polarized wave at 0.34 THz is incident vertically, the characteristics of coding metasurface elements are mainly affected by the DSRR. The DSRR is rotated to meet the requirements of 3-bit Pancharatnam-Berry phase coding. The coding sequence is designed to generate vortex beams with the topological charge l=± 1 at a specific angle. The VO2’s state is changed to a metallic state, the DSRR can be equivalent to a metal ring. When the orthogonal linearly polarized waves at 0.74 THz are incident vertically, the characteristics of coding metasurface elements are mainly affected by the cross structure. Because of its anisotropy, four different 2-bit coding metasurface elements can be obtained respectively by changing the length of the horizontal arm and the vertical arm. The design of appropriate coding sequences can realize the radar cross section reduction of the x-polarized wave and the beam splitting of the y-polarized wave, and the results have broadband characteristics. Multiple coding sequences can be designed by specialcharacteristics of the coding metasurface, then various expected functions can be realized on the same metasurface. To a certain extent, it solves the problem of single function of ordinary metasurface devices, and paves a novel way to the development of THz multi-function systems.

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Fentanyl Exerts an Antitumor Effect on Papillary Thyroid Cancer by Regulating the miR-204/KLF5 Axis

Cited by 3 publications

References 29 publications

Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives

Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives

Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy

Vanadium dioxide based terahertz dual-frequency multi-function coding metasurface

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