2023
DOI: 10.1111/adb.13350
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Fentanyl‐induced respiratory depression in rodents is inhibited by bioabsorbable, subcutaneous naltrexone implants at 3.5 months

Jeffrey D. Benner,
Steven M. Cohen,
Joseph A. Hollenbaugh
et al.

Abstract: The aim of this study is to determine if extended‐release, bioabsorbable, subcutaneous naltrexone (NTX) implants inhibit respiratory depression after an IV injection of fentanyl. Bioabsorbable implants fabricated from two different release‐controlling polymers, poly‐D‐L‐lactide (PDLLA) and polycaprolactone (PCL), alone (placebo) or containing NTX, were subcutaneously implanted in Sprague Dawley rats. After 3.5 months of implantation, the rodents were administered an IV bolus of fentanyl through the tail vein. … Show more

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