Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR

Li, Ai-xiang; Xin, Wenqi; Ma, Chi

doi:10.1016/j.bbrc.2015.08.068

Cited by 30 publications

(24 citation statements)

References 23 publications

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“…Fentanyl and remifentanil decreased NK cell activity, but didn’t suppress immune resistance at low doses [ 10 , 26 , 27 ]. Furthermore, fentanyl has demonstrated anti-tumor property by inhibiting cancer cell migration and invasion [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study

et al. 2018

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BackgroundVascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) have been involved in tumor growth and metastasis. Sevoflurane may promote angiogenesis, whereas propofol can present an anti-angiogenic effect. In this study, we compared the effects of propofol/remifentanil-based total intravenous anesthesia (TIVA) and sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β, as well as recurrence- free survival (RFS) rates in the patients undergoing breast cancer surgery.MethodsEighty female patients undergoing breast cancer resection were enrolled and randomized to receive either sevoflurane-based inhalational anesthesia (SEV group) or propofol/remifentanil-based TIVA (TIVA group). The serum concentrations of VEGF-C and TGF-β before and 24 h after surgery were measured and RFS rates over a two-year follow-up were analyzed in both groups. The postoperative pain scores assessed using a visual analogue scale (VAS) and the use of perioperative opioids were also evaluated.ResultsAlthough VAS scores at 2 h and 24 h after surgery were comparable between the two groups, there were more patients receiving postoperative fentanyl in the TIVA group (16[40%]) compared with the SEV group (6[15%], p = 0.023). VEGF-C serum concentrations increased after surgery from 105 (87–193) pg/ml to174 (111–281) pg/ml in the SEV group (P = 0.009), but remained almost unchanged in the TIVA group with 134 (80–205) pg/ml vs.140(92–250) pg/ml(P = 0.402). The preoperative to postoperative change for VEGF-C of the SEV group (50 pg/ml) was significantly higher than that of the TIVA group (12 pg/ml) with a difference of 46 (− 11–113) pg/ml (P = 0.008). There were also no significant differences in the preoperative and postoperative TGF-β concentrations between the two groups. The two-year RFS rates were 78% and 95% in the SEV and TIVA groups (P = 0.221), respectively.ConclusionIn comparison with sevoflurane-based inhalational anesthesia, propofol/remifentanil -based total intravenous anesthesia can effectively inhibit the release of VEGF-C induced by breast surgery, but didn’t seem to be beneficial in the short-term recurrence rate of breast cancer.Trial registrationChictr.org.cn ChiCTR1800017910. Retrospectively Registered (Date of registration: August 20, 2018).

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Section: Discussionmentioning

confidence: 99%

Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study

et al. 2018

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“…Fentanyl is widely used in clinic as an anesthetic, particularly in the treatment of different types of cancer, including ESCC (18). Previous studies have reported the potential antitumor effects of fentanyl, but there are limited reports regarding its role in ESCC (6)(7)(8)(9)(10). The results of the present study suggested that the mechanisms of the anti-proliferation and anti-invasion effects of fentanyl were associated with miR-302b expression in ESCC Eca109 and TE1 cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it is considered to be an effective analgesic for breakthrough cancer pain in patients with terminal cancer (5). Recently, an increasing number of studies reported that fentanyl is able to inhibit cancer progression, including proliferation, cell cycle, apoptosis, invasion and chemotherapy sensitivity (6)(7)(8)(9)(10). In brief, fentanyl may serve a potential therapeutic role in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Fentanyl inhibits proliferation and invasion via enhancing miR‑302b expression in esophageal squamous cell carcinoma

Wang

Zhang

2018

Oncol Lett

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Fentanyl is one of the most commonly used intravenous anesthetic agents during cancer resection surgery, but the effect of fentanyl on esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of the present study was to investigate the involvement of microRNA 302b (miR-302b) in the anti-proliferation and anti-invasion effects of fentanyl in ESCC. In the present study, the effects of fentanyl on cell proliferation, apoptosis and invasion were detected using MTT assays, flow cytometry and Transwell assays in ESCC Eca109 and TE1 cell lines. Subsequently, expression of miR-302b was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). RT-qPCR and western blot analysis were performed in order to evaluate the expression of ErbB4, a target of miR-302b. Furthermore, anti-miR were used to inhibit miR-302b in fentanyl-treated ESCC cells in order to evaluate the role of miR-302b in the effect of fentanyl on malignant behaviors. Fentanyl inhibited the proliferation of Eca109 and TE1 cells in a dose-and time-dependent manner. Following exposure to fentanyl for 48 h, Eca109 and TE1 cells exhibited increased apoptosis and decreased invasion. Furthermore, fentanyl upregulated miR-302b expression, but downregulated ErbB4 expression. Finally, loss of miR-302b using the anti-miR technique reversed the effect of fentanyl on cell proliferation, apoptosis and invasion in the two ESCC cell lines. Taken together, the results of the present study indicated that fentanyl inhibits the proliferation and invasion of ESCC cells through upregulation of miR-302b.

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“…These results also confirm the accuracy of our results. For other genes that are not included in the Sanger database, we also confirm their important role in cancer-related biological processes through literature verification, such as ETS1 (Watabe et al, 1998;Fujimoto et al, 2004;Zhang et al, 2014;Li et al, 2015) and RHOA (Lee et al, 2015;Zeng et al, 2015;Sun et al, 2016) in hallmark "Activating Invasion and Metastasis".…”

Section: Validation Of Chg Datamentioning

confidence: 55%

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

et al. 2020

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Background: The analysis of cancer diversity based on a logical framework of hallmarks has greatly improved our understanding of the occurrence, development and metastasis of various cancers. Methods: We designed Cancer Hallmark Genes (CHG) database which focuses on integrating hallmark genes in a systematic, standard way and annotates the potential roles of the hallmark genes in cancer processes. Following the conceptual criteria description of hallmark function the keywords for each hallmark were manually selected from the literature. Candidate hallmark genes collected were derived from 301 pathways of KEGG database by Lucene and manually corrected. Results: Based on the variation data, we finally identified the hallmark genes of various types of cancer and constructed CHG. And we also analyzed the relationships among hallmarks and potential characteristics and relationships of hallmark genes based on the topological structures of their networks. We manually confirm the hallmark gene identified by CHG based on literature and database. We also predicted the prognosis of breast cancer, glioblastoma multiforme and kidney papillary cell carcinoma patients based on CHG data. Conclusions: In summary, CHG, which was constructed based on a hallmark feature set, provides a new perspective for analyzing the diversity and development of cancers.

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Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR

Cited by 30 publications

References 23 publications

Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study

Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study

Fentanyl inhibits proliferation and invasion via enhancing miR‑302b expression in esophageal squamous cell carcinoma

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

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