Fentanyl versus midazolam added to bupivacaine for spinal analgesia in children undergoing infraumbilical abdominal surgery: A randomized clinical trial

AbdelRady, Marwa Mahmoud; Abdelrahman, Khaled A; Ali, Wesam Nashat; Ali, Ahmed M.; Elfadl, Ghada Mohammad Abo

doi:10.1080/11101849.2022.2031810

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Se publicó recientemente un ensayo clínico en pacientes pediátricos de entre 6 y 8 años programados para cirugía abdominal infraumbilical en el que se comparó la administración de midazolam (0,5 mg) y fentanil (0,2 ug/kg) intratecales en conjunto con bupivacaína al 0,5% (0,3 mg/kg). Se encontró que el grupo de pacientes a quienes se les administró midazolam tuvo un mayor tiempo hasta el primer requerimiento analgésico (80 minutos), mayor satisfacción de la familia y menor consumo total de analgésicos en comparación con el grupo de fentanil, sin diferencias en efectos adversos importantes [38]. Sin embargo, hace falta más evidencia de alta calidad que compare este medicamento con otros coadyuvantes para esclarecer su dosis apropiada, beneficios y efectos adversos con mayor certeza.…”

Section: Midazolamunclassified

Coadyuvantes en anestesia espinal

Burbano¹,

Gómez²

2023

Rev. chil. anest.

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Objectives: To Synthesize the most used adjuvants in spinal anesthesia, summarize the mechanisms of action, indication, dose, adverse events, and safety outcomes described. Methodology: Non-systematic review in the medline, embase, central and Scielo databases without time or language limits, focused on adjuvants in spinal anesthesia, systematic reviews and meta-analyses were selected in order of priority in case they did not have them. Controlled clinical trials were chosen and finally observational studies. Results: 36 original and secondary studies met the inclusion criteria; a narrative review was carried out with the main findings of the same according to the authors. Conclusions: Adjuvants for spinal anesthesia are drugs that are intended to take advantage of a synergistic effect with local anesthetics that can improve the latency of action onset, duration of neuraxial blockade and reduce adverse effects, they stand out for their effects and better safety profile opioid adjuvants.

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Section: Midazolamunclassified

Coadyuvantes en anestesia espinal

Burbano¹,

Gómez²

2023

Rev. chil. anest.

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Comparison of Fentanyl With Midazolam As Adjuvants to Levobupivacaine in Spinal Anesthesia for Cesarean Sections: A Randomized Controlled Trial

Yazhini,

Venkatraman,

Kandan

2024

Cureus

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Background and objectivesSpinal anesthesia stands as a cornerstone for patients undergoing lower segment cesarean section (LSCS), offering advantages like faster onset and high block density. Levobupivacaine, known for its high potency and long-acting nature, has a slower onset. The safety of intrathecal fentanyl or midazolam is evaluated as an adjuvant to levobupivacaine in parturients. This study aims to compare the duration of postoperative analgesia provided by fentanyl or midazolam added to 0.5% hyperbaric levobupivacaine in elective cesarean sections. Secondary objectives include evaluating the onset and duration of sensory and motor blockade and the incidence of nausea and vomiting. Identifying the more effective adjuvant will help optimize spinal anesthesia protocols, improve postoperative outcomes, and enhance patient comfort and recovery. Methods

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Fentanyl versus midazolam added to bupivacaine for spinal analgesia in children undergoing infraumbilical abdominal surgery: A randomized clinical trial

Cited by 2 publications

References 23 publications

Coadyuvantes en anestesia espinal

Coadyuvantes en anestesia espinal

Comparison of Fentanyl With Midazolam As Adjuvants to Levobupivacaine in Spinal Anesthesia for Cesarean Sections: A Randomized Controlled Trial

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