Fenugreek affects the activity of <i>β</i>‐glucuronidase and mucinase in the colon

Devasena, T; Menon, Venugopal P.

doi:10.1002/ptr.1331

Cited by 49 publications

(22 citation statements)

References 16 publications

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“…Besides, recent studies showed that also some of them have potential to alter the GUS activity. Experimental evidences suggest that compounds in some dietary spices [8], d-glucaro-1,4-lactone in vegetables [9] had a decreasing role on the of ␤-glucuronidase activity. Besides, it was reported that activity of GUS enzyme extracted from the plant tissues was also influenced by interfering secondary plant compounds.…”

Section: Introductionmentioning

confidence: 99%

Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor

Kavak

Altıok

Bayraktar

et al. 2010

Journal of Molecular Catalysis B: Enzymatic

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a b s t r a c tIn this study, inhibition of Escherichia coli glucuronidase (GUS) by a plant extract of Pistacia terebinthus was investigated. P. terebinthus (from Karaburun region in Turkey) leaf extract exhibits various bioactivities, such as antioxidant, antimicrobial and cytotoxic property because of its flavonoid, phenolic and alkaloid contents. HPLC analyses were performed to evaluate the composition of the extract and main flavonoid compounds such as luteolin, luteolin-7-glucoside and apigenin-7-glucoside were detected in extract. GUS activity and kinetic data of the GUS were obtained by measuring rate of production of resulting fluorescent 4-methylumbelliferone (4-MU) and phenolphthalein fluorometrically and spectrophotometrically, respectively. Plant leaves showed higher antioxidant capacity as 85 TEAC (trolox equivalent antioxidant capacity) value and higher antimicrobial activity towards Staphylococcus aureus. 92.4% GUS enzyme inhibition was achieved with 8.3 g ml −1 crude extract concentration, where IC 50 value was found as 2.1 (±0.2) g ml −1 . Kinetic studies by nonlinear regression revealed that inhibition type caused by plant extract was mixed type (noncompetitive and competitive together). K m and V max values were 96.94 ± 9.68 nM and 7.81 ± 0.16 nmol min −1 mg −1 , respectively. Inhibition constant (˛K i ) was found as 7.00 ± 0.93 nM having˛value 2.17 ± 0.93. Our results may provide useful information regarding the inhibition of microbial GUS activity, preventing deglucuronidation and reducing possible cancer risk by bioactive P. terebinthus crude extract.

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Section: Introductionmentioning

confidence: 99%

Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor

Kavak

Altıok

Bayraktar

et al. 2010

Journal of Molecular Catalysis B: Enzymatic

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“…Incorporation of fenugreek seed in the diet modulates the activities of β-glucoronidase and mucinase and inhibit coloncarcinogenesis.Activity of β-glucoronidase significantly decreased the free carcinogens which were not affective on colonocytes. Mucinase helped in hydrolysing the protective mucin and this was correlated with the presence of fibre, flavanoids and saponins (52). Since the antioxidant activity of a plant is due to its active phytochemicals, it has been announced that fenugreek possesses a great antioxidant property that has a beneficial effect on the liver and pancreas because of its phenolic and flavonoid compound.…”

Section: Anticarcinogenic Effect and Antioxidant Activitymentioning

confidence: 99%

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

Khorshidian¹,

Asli²,

Arab³

et al. 2016

Nutr Food Sci Res

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A B S T R A C TFenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is an annual herb with white flowers and hard, yellowish brown and angular seeds, known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical.

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“…T. foenumgraecum (fenugreek) is an important spice in India, Egypt, Saudi Arabia, Iran, Armenia and Turkey. Trigonella seeds are bitter, mucilaginous, aromatic, tonic, emollient and anti-carcinogenic agents 16 . Antimicrobial, antioxidant and anti-inflammatory properties of the plants of Uttarakhand State were investigated [17][18][19][20] .…”

Section: Correspondence To Author: Asima Shabanmentioning

confidence: 99%

Untitled

2014

IJPSR

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Many infectious diseases are known to be treated with herbal remedies throughout the history of mankind. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. Traditional system of medicine is found to have utilities as many accounts. Due to population rise adequate supply of drug and high cost of treatment in side effect along with drug resistance has been encountered in synthetic drugs, which has lead to an elevated emphasis for the use of plants to treat human diseases. A major part of the total population in developing countries still uses traditional folk medicine for different diseases obtained from plant resources. Due to the indiscriminate use of antimicrobial drugs, the emergency of human pathogenic microorganism's resistance has been increased. According to WHO, as many as 80% of world's population living in rural areas rely on herbal traditional medicines as their primary healthcare, the properties and uses of medicinal plants are interestingly growing. Thus, due to prevalence of microbial resistance in today's era and search for new antimicrobial agents, the aim of the study was localized on the screening of solvent extracts of some Indian medicinal plants viz. Terminallia arjuna, Withania somnifera, Emblica officinalis, Ocimum gratissimum and Trigonella foenum graecum prepared in methanol and petroleum ether against drug resistant pathogens. The results confirmed the antimicrobial potential of plants against the pathogens studied at concentration 100 mg/ml.

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Fenugreek affects the activity of β‐glucuronidase and mucinase in the colon

Cited by 49 publications

References 16 publications

Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor

Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

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