Fenugreek gum derivatives with improved bioadhesion and controlled drug release: In vitro and in vivo characterization

Bassi, Pallavi; Kaur, Gurpreet

doi:10.1016/j.jddst.2015.06.006

Cited by 24 publications

(22 citation statements)

References 49 publications

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“…The peaks at 1.23 ppm and 3.34 ppm belonged to unmodified FG. The peak intensity between 0.85 ppm and 1.3 ppm was also increased in FG-C 18 . The 1 H-NMR of FG-C 18 showed typical signals of both FG and stearic acid.…”

Section: H-nmr Spectrummentioning

confidence: 84%

“…As shown in Figure 2(a,b), FG and FG-C 18 displayed typical strong peaks at 3509 cm À1 for OH stretching, 2898 cm À1 due to C-H stretching, and 1658 cm À1 corresponded to OH stretching [17]. The peaks at 1426 cm À1 suggested C-H bending vibrations [18]. The new absorption at 1759 cm À1 (acetyl group) and 1186 cm À1 in Figure 2 characteristic peaks of CH 3 at 2998 cm À1 , CH 2 at 2947 cm À1 , CH bending vibrations at 1457 cm À1 , characteristic peaks between 1390 cm À1 and 1350 cm À1 for methyl and a weak C-H stretching of methylene at 2883 cm À1 [19].…”

Section: Fourier Transform Infrared Spectramentioning

confidence: 89%

“…Self-assembled FG-C 18 NMs loaded with or without coumarin-6 (C6) was prepared using an ultrasonication method. Briefly, 25 mg FG-C 18 was completely dispersed in 10 ml water by magnetic stirring for 4 h at room temperature.…”

Section: Preparation Of Fg-c 18 Nanomicellesmentioning

confidence: 99%

“…The average particle size, polydispersity index (PDI) and zeta potential of FG-C 18 NMs were determined using a Zeta Sizer (Nano-ZS90, Malvern Instruments, UK). A transmission electron microscope (TEM, H-600-4, HITACHI, Tokyo, Japan) was utilized to observe the morphology of FG-C 18 NMs after staining by 2% phosphotungstic acid solution. Primary stability of particles at 4 C or 37 C was evaluated by monitoring the change of size and PDI at different time intervals.…”

Section: Characterization Of Fg-c 18 Nmsmentioning

confidence: 99%

“…The trypsinized cells were resuspended in the culture medium for the following tests. The cytotoxicity and cellular uptake of FG-C 18 NMs were preliminarily evaluated using HepG2 cells as ASGP-R overexpressing cell line and MCF-7 cells as a negative control (low expression of ASGP-R) [15]. In brief, HepG 2 or MCF-7 cells were seeded in a 96-well plate at a density of 3 Â 10 3 cells/well in DMEM with 10% FCS and incubated at 37 C for 24 h. Subsequently, the cells were treated with 100 mL FG-C 18 suspension ranging from 0.1 to 100 lg/ml.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery

Zhou

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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The objective of this study was to hydrophobically modify fenugreek gum (FG) and to further evaluate the potential application of the obtained derivative in liver-targeted drug delivery system. Stearic acid (C 18 ) was conjugated with FG (FG-C 18 ) by a simple esterification reaction. The obtained FG-C 18 was then characterized on its chemical structure by Fourier transform infrared spectroscopy and 1 H-nuclear magnetic resonance. The self-assembled nanomicelles (NMs) of FG-C 18 in water were prepared by an ultrasonication method. The average diameter and zeta potential of FG-C 18 NMs were 196.70 ± 6.12 nm and À31.79 ± 1.58 mV, respectively. FG-C 18 NMs appeared as spherical particles under transmission electron microscopy and possessed a critical micellar concentration of 0.042 mg/ml by pyrene fluorescence probe method. A low toxicity of FG-C 18 was revealed on both HepG2 and MCF-7 cells at 0.1-100 mg/ ml. Haemolysis of FG-C 18 was less than 5%. Cellular uptake of coumarin-6 into HepG2 cells was enhanced by treating with C6-loaded FG-C 18 NMs compared to free coumarin-6. These results suggest that FG-C 18 have a potential application for a liver targeted drug delivery. ARTICLE HISTORY

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Section: H-nmr Spectrummentioning

confidence: 84%

Section: Fourier Transform Infrared Spectramentioning

confidence: 89%

Section: Preparation Of Fg-c 18 Nanomicellesmentioning

confidence: 99%

Section: Characterization Of Fg-c 18 Nmsmentioning

confidence: 99%

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery

Zhou

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Fenugreek (Trigonella foenum graecum) gum: A functional ingredient with promising properties and applications in food and pharmaceuticals—A review

et al. 2022

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Fenugreek (Trigonella foenum graecum) is an annual plant belonging to the family Leguminosae or Fabaceae. The seeds of fenugreek contain 26.8% soluble fiber chemically identified as galactomannans with properties similar to soluble fiber of guar seeds and psyllium husk and so on. Galactomannans are biopolymers consisting of linear core poly (1,4)‐β‐D‐mannan backbone having varying degrees of D‐galactosyl substituents attached by 1,6‐glycosidic linkages. Different galactomannans derived from various legumes usually differ in molecular weight, ratio of mannose to galactose, and the mode and place of linkages of galactose moieties to the mannan backbone. Fenugreek gum has a galactose to mannose ratio of 1:1, showing the highest amount of galactose resulting in its highest water solubility compared with guar and locust bean gum. It suggested that the galactose and mannose moieties are linked uniformly in fenugreek gum resulting in maximum hydration and solubility. This M/G ratio affects the physicochemical properties of galactomannans and is inversely related to the solubility of gum. Galactomannans sterically stabilize the emulsions against flocculation and coalescence by getting adsorbed onto oil droplets. In addition to this, galactomannans are all found to exhibit some surface, interfacial, and emulsification activities. Because of these properties, it is preferred over other natural hydrocolloids as an excellent ingredient for various food applications. As a hydrocolloid, fenugreek gum provides texture, appeal, gelling, thickening, emulsifying, stabilizing, and encapsulating properties. In the present review, we summarized the extraction, purification, chemical, functional properties, molecular structure, thermal and rheological behavior of gum isolated from fenugreek seeds, and then vital application of this traditional source of hydrocolloids in food, pharmaceutical, and other industries.

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High Cycling Performance Li‐S Battery via Fenugreek Gum Binder Through Chemical Bonding of the Binder with Polysulfides in Nanosulfur@CNFs Cathode

Yin

et al. 2020

ChemistrySelect

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The dissolution and diffusion of lithium polysulfides are one of the main intrinsic bottlenecks in the development of lithiumsulfur (LiÀ S) batteries with long term cycling stability. Appropriate binders could play a key role of anchoring the lithium polysulfides in S-cathode through strong chemical bonds, thus boosts the electrochemical performance of LiÀ S battery. Herein, we report a new binder (fenugreek gum, FG) that has enhanced significantly the cycling performance of LiÀ S batteries with S@CNFs composite as cathode. The LiÀ S cell with FG binder delivers a large initial capacity of 900 mAh g À 1 at 2 C, and a reversible capacity retention of 45.6 % after 1300 cycles, superior to the cycling performance of LiÀ S cell with conventional PVDF or previous reported guar gum (GG) binder. This enhancement in cycling performance of LiÀ S batteries could be attributed to the formation of the SÀ O and LiÀ O bonds between the O-relevant functional groups in the binder and the polysulfides in S-cathode as manifested by XPS data of the discharged and charged electrodes. Furthermore, the tensile strain rate of the FG binder is as high as 32 %, which can effectively restrain the volume expansion of the S-cathode during the discharge/charge process and ensure the integrity of the electrode.

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Fenugreek gum derivatives with improved bioadhesion and controlled drug release: In vitro and in vivo characterization

Cited by 24 publications

References 49 publications

Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery

Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery

Fenugreek (Trigonella foenum graecum) gum: A functional ingredient with promising properties and applications in food and pharmaceuticals—A review

High Cycling Performance Li‐S Battery via Fenugreek Gum Binder Through Chemical Bonding of the Binder with Polysulfides in Nanosulfur@CNFs Cathode

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