Fenugreek seeds reduce aluminum toxicity<i>associated with renal failure in rats</i>

Belaïd-Nouira, Yosra; Bakhta, Hayfa; Haouas, Zohra; Flehi-Slim, Imen; Cheikh, Hassen Ben

doi:10.4162/nrp.2013.7.6.466

Cited by 40 publications

(26 citation statements)

References 36 publications

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“…Several studies have reported that Al accumulates in mammalian tissues such as brain, bone, liver and kidney (Belaïd-Nouira et al, 2013). As a result, Al causes alterations in the biliary secretory function and an increase in oxidative stress in hepatic tissues (Gonzalez et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

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The main sources of human exposure to aluminum are found in the extensive presence of the metal in the environment and its growing industrial applications. The present study was carried out to determine the effectiveness of the Thymus vulgaris L. extract in alleviating aluminum chloride (AlCl 3 ) toxicity on biochemical and antioxidant parameters. The experiment's rats were divided into five groups: a control group; an intoxicated group (300 mg AlCl 3 /kg bw); and three other groups which were given AlCl 3 (300mg/kg/bw) then T. vulgaris. L extract (T.v), Malic Acid (MA) and Vitamin E (Vit E) at a concentration of 150mg/kg/bw. Each group was given its respective dosage, daily for 90 days. The results showed a significant decrease in the body/liver/kidney weights, the plasma total protein (T. Protein) and albumin (Alb) levels (p≤0.05) in the intoxicated rats group. However, a significant increase in the plasma uric acid (Uac), alkaline (AlP) and acid phosphatase (AcP) levels was noted (p≤0.05) in the same group. The amount of aluminum, TBARS and nitrate/nitrite (NO) in the liver and kidney tissues of the rats treated with AlCl 3 was also found to have increased (p≤0.05), while the levels of glutathione peroxidase (GSH-Px) and glutathione transferase (GSH-St) have decreased significantly (p≤0.05). These altered parameters were restored in the rats treated with the T. vulgaris L. extract. Therefore, due to these beneficial effects, T. vulgaris L. could potentially be used to antagonize AlCl 3 toxicity.

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Section: Discussionmentioning

confidence: 99%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

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“…The continuous use of chemical inputs such as pesticides has resulted in great damage to the environment in addition to human ill‐health. The clinical impact of pesticides is marked by an increasing risk of myocardial injury and congestive heart failure, chiefly caused by reactive oxygen species generation . However, many studies have reported the benefits of medicinal plants in the treatment of cardiovascular diseases due to their richness in bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

“…The treatments were carried out for a period of 30 days. The dose duration of TMX treatment was previously shown to be toxic but not lethal . The doses of FWEP (100 mg/kg and 200 mg/kg of diet) were shown in previous studies to be effective in lowering toxicity …”

Section: Methodsmentioning

confidence: 98%

“…Clinical and experimental studies have documented several beneficial actions of this plant, such as antiatherosclerotic, anti‐inflammatory, antimicrobial, antioxidant, anticancerous, antidiabetic, and hypocholesterolemic effects . According to previous studies, Trigonella foenum graecum ameliorates acrylamide‐induced oxidative stress, inflammation and DNA damage, protects against deltamethrin‐induced hematological, biochemical, and oxidative stress in rats liver, kidney, and brain and alleviate aluminum toxicity associated with renal failure . Trigonella seeds, contain about 23%–26% protein, 6%–7% fat, and 58% carbohydrates, of which 25% are dietary fiber .…”

Section: Introductionmentioning

confidence: 98%

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Cardiotoxicity and myocardial infarction‐associated DNA damage induced by thiamethoxam in vitro and in vivo: Protective role of Trigonella foenum‐graecum seed‐derived polysaccharide

Feki

Saad

Bkhairia

et al. 2018

Environmental Toxicology

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The risk of pesticides on the human health and environment has drawn increasing attention. Today, new tools are developed to reduce pesticide adverse effects. This study aimed to evaluate the toxicity induced by, thiamethoxam (TMX), and the cytoprotective effect of a novel polysaccharide, named fenugreek seed water polysaccharide (FWEP) in vitro using H9c2 cardiomyoblastes and in vivo using Wistar rat model. Animals were assigned into four groups per eight rats each: group 1 served as a control group, group 2 received TMX, group 3, and group 4 received both FWEP and TMX tested at two doses (100 and 200 mg/kg, respectively). Regarding the in vitro study, our results demonstrated that TMX induced a decrease in H9c2 cell viability up to 70% with the highest concentration. In vivo, TMX injection induced marked heart damage noted by a significant increase in plasma lactate dehydrogenase, creatine phosphokinase, troponin-T, aspartate amino transferase activities, cholesterol, and triglyceride levels. Concomitant alterations in cardiac antioxidant defense system revealed depletion in the levels of glutathione and non-protein thiol and an increase in the activity of superoxide dismutase, catalase, and glutathione peroxidase. Similarly, a significant increase in heart lipid, malondialdehyde, advanced oxidation protein product and in protein carbonyls levels was also noted. In addition, heart tissues histo-architecture displayed major presence of apoptosis and necrosis as confirmed by DNA degradation. However, supplementation with FWEP alleviated heart oxidative damage and genotoxicity. In this manner, ABTS radical-scavenging activity, linoleic acid oxidation tests and heart genomic and DNA nicking assay had proved FWEP strong antioxidant potential. In conclusion, FWEP provided significant protection against TMX-induced heart injury, and could be a useful and efficient agent against cardiotoxicity and atherosclerosis. K E Y W O R D S cardiotoxicity, cytotoxicity, oxidative stress, polysaccharide, thiamethoxam

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“…Both zinc and aluminium were incriminated in renal pathology, especially after prolonged usage at higher doses especially in kidney failure patients [23]. Thus, urea, electrolyte and creatinine levels were analysed after the 28-day oral dosing of the rats.…”

Section: Resultsmentioning

confidence: 99%

Toxicity evaluation of zinc aluminium levodopa nanocomposite via oral route in repeated dose study

et al. 2014

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Nanotechnology, through nanomedicine, allowed drugs to be manipulated into nanoscale sizes for delivery to the different parts of the body, at the same time, retaining the valuable pharmacological properties of the drugs. However, efficient drug delivery and excellent release potential of these delivery systems may be hindered by possible untoward side effects. In this study, the sub-acute toxicity of oral zinc aluminium nanocomposite with and without levodopa was assessed using the Organization for Economic Co-operation and Development guidelines. No sign or symptom of toxicity was observed in orally treated rats with the nanocomposite at 5 and 500 mg/kg concentrations. Body weight gain, feeding, water intake, general survival and organosomatic index were not significantly different between control and treatment groups. Aspartate aminotransferase (AST) in 500 mg/kg levodopa nanocomposite (169 ± 30 U/L), 5 mg/kg levodopa nanocomposite (172 ± 49 U/L), and 500 mg/kg layered double hydroxides (LDH) nanocomposite (175 ± 25 U/L) were notably elevated compared to controls (143 ± 05 U/L); but the difference were not significant (p > 0.05). However, the differences in aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio of 500 mg/kg levodopa nanocomposite (0.32 ± 0.12) and 500 mg/kg LDH nanocomposite (0.34 ± 0.12) were statistically significant (p < 0.05) compared to the control (0.51 ± 0.07). Histology of the liver, spleen and brain was found to be of similar morphology in both control and experimental groups. The kidneys of 500-mg/kg-treated rats with levodopa nanocomposite and LDH nanocomposite were found to have slight inflammatory changes, notably leukocyte infiltration around the glomeruli. The ultra-structure of the neurons from the substantia nigra of nanocomposite-exposed group was similar to those receiving only normal saline. The observed result has suggested possible liver and renal toxicity in orally administered levodopa intercalated nanocomposite; it is also dose-dependent that needs further assessment.

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Fenugreek seeds reduce aluminum toxicityassociated with renal failure in rats

Cited by 40 publications

References 36 publications

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Cardiotoxicity and myocardial infarction‐associated DNA damage induced by thiamethoxam in vitro and in vivo: Protective role of Trigonella foenum‐graecum seed‐derived polysaccharide

Toxicity evaluation of zinc aluminium levodopa nanocomposite via oral route in repeated dose study

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