Feocromocitoma: experiencia clínica de tres décadas en un estudio multicéntrico

Iglesias, Pedro; Santacruz, Elisa; Garcia-Sancho, Paula; Marengo, Agustina Pia; Guerrero-Pérez, Fernando; Pián, Héctor; Fajardo, Carmen; Villabona, Carles; Díez, Juan J.

doi:10.1016/j.rce.2019.12.016

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…With respect to gender, it is more frequent in women in both groups, the index cases and the familial group, but without a statistically significant difference, as has been described previously in other studies [ 21 , 22 , 23 , 24 ]. A particular finding is the association between being male and having a familial PHEO, with a probability 2.4 times higher, a fact not previously described in the literature.…”

Section: Discussionsupporting

confidence: 81%

Differences between Patients with Sporadic and Familial Pheochromocytoma—Is It Possible to Avoid Genetic Testing in Certain Patients?

Muñoz,

Febrero,

Abellán

et al. 2024

Biomedicines

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Background: Pheochromocytoma (PHEO) is a rare neuroendocrine tumour with a strong genetic link, which therefore may modify its clinical behaviour and prognosis. The aim of the study is to evaluate the epidemiological and clinical differences between patients with sporadic and familial PHEO, as well as the specific differences in the index cases. Methods: A retrospective analysis of 136 patients in a tertiary hospital (1984–2021). Epidemiological, clinical, and histological variables were analysed. Statistics: SPSS 28.0 software was used. Univariate and multivariate logistic regression analyses were performed. p < 0.05 was considered statistically significant. Results: 64.71% of the cases (n = 88) presented a genetic mutation (familial cases). Additionally, 32.39% (n = 23) corresponded to index cases and the rest to screening cases. The main differences between patients with familial and sporadic PHEO were age (OR = 0.93 (0.89–0.97)), blood pressure-related symptoms (OR = 0.22 (0.06–0.89)), bilaterality (OR = 15.49 (3.76–63.84)), and size (OR = 0.70 (0.54–0.92)). Among patients with sporadic PHEO and index cases, only bilaterality was significant (OR = 13.53 (1.24–144.34)). Conclusions: Patients with familial PHEO diagnosed by screening differ from sporadic cases in terms of age, clinical features, and size. However, patients with sporadic PHEO only differ from index cases by a lower presence of bilaterality, which reaffirms the importance of genetic screening of patients with PHEO and their relatives.

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