FePt Nanoparticles Embedded in Metal–Organic Framework Nanoparticles for Tumor Imaging and Eradication

Abstract

In the tumor microenvironment (TME), an efficient Fenton reaction agent could have attractive tumor therapeutic efficacy, which is primarily based on delivering drugs to the tumor accurately and depressing undesirable side effects. Here, a metal− organic framework (MOF), with good biocompatibility and high loading capacity, with encapsulated FePt NPs (FePt-MOF NCs) and face-centered cubic (fcc)-FePt was successfully designed to eradicate cancer cells. The as-prepared multifunctional FePt-MOF NCs serve as a nanotheranostic agent for magnetic resonance/computed tomography (MR/CT) dual-modal imaging based on superparamagnetism and cancer therapy due to the well-known Fenton reactions. The drug nanodelivery system based on MOFs was able to safely deliver on the basis of intravenous administration. Because of its high sensitivity to acidic environments, the FePt-MOF would collapse and further release Fe and Pt ions, which would effectively trigger the Fenton reaction to produce plentiful toxic hydroxyl radicals in the acidic tumor microenvironment. On the one hand, the radicals could result in apoptotic cell death, whereas, on the other hand, they also lure the cumulation of lipid peroxides, causing tumor cell ferroptosis. These results indicated the great potential of the FePt-MOF NCs as a multifunction platform for tumor therapeutic and image applications.

Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

“…As shown in Figure 1 , the NMOF545 was first synthesized according to previous studies ( Yu et al, 2020 ), and then the ultra-small platinum partials were loaded on its surface ( Meng et al, 2020b ). SEM and TEM measured the morphologies of the NMOF545 and NMOF545@Pt.…”

“…200 μl samples (10 mg/kg) were injected into the tumor-bearing mice by intravenous injection from the tail vein before experiments. According to previous similar studies, the time points for imaging are predetermined ( Meng et al, 2020b ; Wang et al, 2020 ).…”

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

“…[ 23,24 ] Additionally, to develop theranostic nanoplatforms, various imaging strategies have been combined with CDT, such as magnetic resonance imaging (MRI), fluorescence (FL) imaging, and computed tomography (CT) imaging. [ 25,26 ]…”

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

“…Fortunately, ferrous ion (Fe 2+ ) also shows mild catalytic activity for triggering ROS generation within TME. Apart from supporting the certain biological process, it was recently discovered that iron-containing nanomaterials could induce ferroptosis of the tumor cells via the Fenton reaction. − As an indispensable element, the oral lethal dose of Fe 2+ reached 0.45 g/kg in rats, implying the good biosafety of iron-based nanometerials for clinical translation.…”