Feracryl, a new hemostatic polymer, and its interaction with blood plasma proteins

Hemostatic polymers: the concept, state of the art and perspectives

“…In the early 1980s, Russian scientists developed Feracryl®, a poly(acrylic acid) (12) containing up to 2.5% of iron(III) salt coordinated to it. 58,59 The material showed good hemostatic properties, which the authors ascribed to the formation of "articial" clots consisting of Feracryl®/plasma proteins adducts. 58,60 Since the hemostatic activity and the polymer solubility were found to be dependent on the iron content, the authors surmised that the latter might have an active role in the adduct formation.…”

“…58,59 The material showed good hemostatic properties, which the authors ascribed to the formation of "articial" clots consisting of Feracryl®/plasma proteins adducts. 58,60 Since the hemostatic activity and the polymer solubility were found to be dependent on the iron content, the authors surmised that the latter might have an active role in the adduct formation. 61 However, poly(acrylic acid) being highly hygroscopic, one cannot exclude that the absorption of water from blood with the subsequent concentration of coagulation factors and platelets at the bleeding site might play a role in the overall antihemorrhagic effect.…”