In this paper, a new alternative for profiles tracking control considering additive uncertainties is proposed. Based on a previously presented work about a nonlinear and multivariable controller design for a fed-batch bioethanol production, parametric uncertainty and process disturbance are taken into account to find a more reliable control strategy for a successful industrial implementation. To decrease the uncertainties effect, an approach based on the error estimation using Newton’s backward interpolation is included in the design equations. The proposed modification assures the error convergence to zero (demonstration is shown) despite the uncertainties, which is one of the main contributions of this work. A comparison between the new, the original proposal, and another methodology is exposed.