Fermentation of gum arabic by gut microbiota using in vitro colon model

Ahallil, Hammad; Abdullah, Aminah; Maskat, Mohamad Yusof; Sarbini, Shahrul Razid

doi:10.1063/1.5111252

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…For example, the quails fed on a 1.5% wheat branbased diet showed increased relative length of intestinal segments, villi Gum Arabic fermentation in the large intestine of human resulted in increased Bifidobacterium spp. In a latest study, the in vitro application of gum Arabic has been observed to increase the production of SCFAs and antimicrobial activity against clostridium [106].…”

Section: Types Of Dietary Fibers and Their Impact On Gastrointestinal...mentioning

confidence: 99%

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

Ali

et al. 2022

Anim Biosci

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The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce shortchain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health.

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Section: Types Of Dietary Fibers and Their Impact On Gastrointestinal...mentioning

confidence: 99%

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

Ali

et al. 2022

Anim Biosci

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“…Gum Arabic is a non-digestible dietary fiber and is mainly fermented by colonic intestinal bacteria (74)(75)(76).…”

Section: Gum Arabic As Prebiotic Agentmentioning

confidence: 99%

The role of gum Arabic as an anti-inflammatory, antioxidant, and immune modulator in the development of COVID-19: A review

Babiker

Kaddam

Mariod

2022

FFS

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Background: Down-regulation of the lung inflammatory response seems to preserve pulmonary functions and improve survival in COVID-19. The key factor in overcoming the cytokine storm caused by COVID-19 by immunomodulation, rather than immunosuppression. Identifying the right mechanism to manipulate the immune regulatory networks in the lung—with minimal side effects—represents one of the many challenges in the treatment of COVID-19 disease. Immunomodulatory, anti-inflammatory, antioxidant, and gut-regulatory activities are the most significant properties of prebiotics. Therefore, it could be beneficial to consider them as an adjuvant dietary intervention among COVID-19 patients. Understanding the exact mechanism of prebiotic defense against infection and regulation of immune processes involved in COVID-19 are crucial for the development of novel therapeutic agents. Several studies considered Gum Arabic (GA) as a potent prebiotic with cytoprotective properties. This review aims to discuss and display the possibility of utilizing the beneficial effects of GA to modulate COVID-19 pathogenesis.Keywords: COVID-19, Gum Arabic, Immunomodulation, dietary intervention, Gut microbiota, Anti-inflammatory, Antioxidant

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“…However, currently used prebiotics are predominantly fermented in the proximal colon due to their colonization by microbiota with a high saccharolytic potential [ 14 ]. The fermentation of Arabic gum (AG), a water-soluble heteropolysaccharide with high molecular weight, is believed to occur mainly in the distal colon due to its rather complex structure and could, therefore, be a promising prebiotic candidate [ 15 , 16 , 17 ]. This distal fermentation profile was indeed observed by Daguet et al [ 18 , 19 ] upon long-term administration of AG in an in vitro gut model using fecal inocula of IBS (irritable bowel syndrome) and IBD (irritable bowel disease) donors, respectively.…”

Section: Introductionmentioning

confidence: 99%

Co-Supplementation of Baobab Fiber and Arabic Gum Synergistically Modulates the In Vitro Human Gut Microbiome Revealing Complementary and Promising Prebiotic Properties

Duysburgh,

Govaert,

Guillemet

et al. 2024

Nutrients

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Arabic gum, a high molecular weight heteropolysaccharide, is a promising prebiotic candidate as its fermentation occurs more distally in the colon, which is the region where most chronic colonic diseases originate. Baobab fiber could be complementary due to its relatively simple structure, facilitating breakdown in the proximal colon. Therefore, the current study aimed to gain insight into how the human gut microbiota was affected in response to long-term baobab fiber and Arabic gum supplementation when tested individually or as a combination of both, allowing the identification of potential complementary and/or synergetic effects. The validated Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), an in vitro gut model simulating the entire human gastrointestinal tract, was used. The microbial metabolic activity was examined, and quantitative 16S-targeted Illumina sequencing was used to monitor the gut microbial composition. Moreover, the effect on the gut microbial metabolome was quantitatively analyzed. Repeated administration of baobab fiber, Arabic gum, and their combination had a significant effect on the metabolic activity, diversity index, and community composition of the microbiome present in the simulated proximal and distal colon with specific impacts on Bifidobacteriaceae and Faecalibacterium prausnitzii. Despite the lower dosage strategy (2.5 g/day), co-supplementation of both compounds resulted in some specific synergistic prebiotic effects, including a biological activity throughout the entire colon, SCFA synthesis including a synergy on propionate, specifically increasing abundance of Akkermansiaceae and Christensenellaceae in the distal colon region, and enhancing levels of spermidine and other metabolites of interest (such as serotonin and ProBetaine).

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Fermentation of gum arabic by gut microbiota using in vitro colon model

Cited by 7 publications

References 22 publications

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

The role of gum Arabic as an anti-inflammatory, antioxidant, and immune modulator in the development of COVID-19: A review

Co-Supplementation of Baobab Fiber and Arabic Gum Synergistically Modulates the In Vitro Human Gut Microbiome Revealing Complementary and Promising Prebiotic Properties

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