Fermentative Herstellung der α,ω‐Dicarbonsäure 1,18‐Oktadecendisäure als Grundbaustein für biobasierte Kunststoffe

Abstract

Langkettige, ungesättigte Dicarbonsäuren stellen interessante Monomere für die Herstellung von neuen Polyamiden und -estern dar. Chemisch sind diese nur schwer darstellbar, daher stellt die fermentative Herstellung eine attraktive Alternative dar. Durch Untersuchung von Wachstums- und Produktionsparametern konnte der Herstellungsprozess von 1,18-Oktadecendisäure mit dem Stamm Candida tropicalis verbessert und neue Erkenntnisse gewonnen werden

Linear Semicrystalline Polyesters from Fatty Acids by Complete Feedstock Molecule Utilization

“…[9][10][11][12] An efficient and highly regio-as well as chemoselective conversion of an internal double bond into a terminal functional group is a challenge for synthetic chemistry. [13] To this end, palladium(II) complexes of very bulky substituted electron-rich diphosphines catalyze the reaction of ethylene with carbon monoxide and methanol to methylpropionate (methoxycarbonylation) with high rates. [14,15] Remarkably, these catalysts methoxycarbonylate internal octenes to the linear carboxylic acid esters.…”

Long-Chain Polyesters via Chemical Catalytic Conversions of Fatty Acid Esters

“…One possible approach to such long-chain a,m-difunctional compounds is enzymatic m-oxidation of fatty acids (Scheme 2.) (15)(16)(17). Linear aliphatic diacids with the same carbon atom number as the fatty acid starting material, that is an even number usually in the range from 14 to 22 can be obtained.…”

Biotechnological synthesis of long‐chain dicarboxylic acids as building blocks for polymers

“…In case of production of DCA with C. tropicalis defined mineral nutrient [106,108,115,116] as well as so-called ''semi-defined'' media [11,73,109,110,113,117,118] were described. In our studies we described the use of different media (complex and mineral salt) and also feeding strategies like fed batch with constant or exponential feed to increase microbial biomass for higher cell density of C. tropicalis ATCC20962, which leads to a higher production rate of 1,18-octadecenedioic acid [119]. The downstream processing of this DCA is described by Kö rner and Deerberg [120].…”

“…Maximal product concentration (C max ) and maximal production rate of dicarboxylic acid (R max ) are listed below. [119] The formation of DCA in general does not only depend on the supplied fermentation medium but also on the kind of the substrate e.g., alkane and fatty acid chain length. Substrates with shorter chain length can be converted with higher efficiency when compared to long-chain substrates.…”