Fermentative production of gluconic acid in membrane-integrated hybrid reactor system: Analysis of process intensification

Gluconic acid aqueous solution: A bio-based catalytic medium for organic synthesis

“…Most advancements in the fermentative preparation of gluconic acid nowadays are focused on the development of more efficient reactors and purification systems (Pal et al, 2016). Typical microorganisms used for the gluconic acid production are bacteria Acetobacter diazotrophicus (Attwood et al, 1991), Gluconobacter oxydans (Pal et al, 2017;Hou et al, 2018;Yao et al, 2017;Zhou et al, 2019a;Jiang et al, 2017), G. japonicus (Cañete-Rodríguez et al, 2015, Pseudomonas taetrolens (Alonso et al, 2015), Zymomonas mobilis (Ferraz et al, 2001;Silveira et al, 1999), fungi Aspergillus niger (Ajala et al, 2017;Chuppa-Tostain et al, 2018;Ahmed et al, 2015), A. carneus (Tarekegn and Jabasingh, 2019), A. terreus (Dowdells et al, 2010), Penicillium variabile (Crognale et al, 2008), P. puberulum (Ahmed et al, 2015), P. frequentans (Ahmed et al, 2015), and yeast-like fungi Aureobasidium pullulans Rehm, 2006a, 2006b;Anastassiadis et al, 2003).…”

Design of enzymatic cascade processes for the production of low-priced chemicals

“…Current production costs are reported around 1.2-8.5 USD/kg [15], where the fermentation substrate and downstream processing cost contribute to the majority of the cost [16]. In reality, around the 60% of the operational cost is defined by the substrate [17] and 30-40% by the downstream product recovery [18]. Alternative processes for the production of gluconic acid include chemical, electrochemical, catalytic and enzymatic oxidation.…”

“…For fermentation, the most commonly used substrate is hydrolyzed corn starch [16], which is supplemented with additional nutrients such as nitrogen and phosphorus [24]. In reality, both the carbon and the supplementary nutrients have an impact on the substrate cost [17]. Hence, by operating a nonfermentative system, the nutrient cost contribution can be much reduced.…”