Fermented barley β‐glucan regulates fat deposition in Caenorhabditis elegans

Abstract

BACKGROUNDBarley contains a relatively high concentration of the mixed‐linkage (1 → 3) (1 → 4) β‐glucan, which has been reported to be a functional food with prebiotic potential. In the current study we compared the properties of two neutral barley β‐glucans, obtained from raw barley: raw barley β‐glucan (RBG) and Lactobacillus plantarum dy‐1‐fermented barley (FBG).RESULTSMolecular characteristics revealed that the molecular weight of barley β‐glucan decreased from 1.13 × 105 D to 6.35 × 104 D after fermentation. Fermentation also improved the water / oil holding capacity, solubility, and swelling capacity of barley β‐glucan. Both RBG and FBG significantly improved the locomotive behavior of nematodes, thereby increasing their energy consumption and reducing fat deposition – the effect was more significant with FBG. These effects could potentially depend on nhr‐49, TGF‐daf‐7 mediated pathways and so on, in which nhr‐49 factor is particularly required.CONCLUSIONThese results suggested that fermentation may enhance in vitro physiological activities of barley β‐glucan, thereby altering the effects on the lipid metabolism in vivo. © 2020 Society of Chemical Industry

Effect of Lactobacillus plantarum fermented barley on plasma glycolipids and insulin sensitivity in subjects with metabolic syndrome

“…The fiber in barley can promote intestinal peristalsis, keep the balance of intestinal microbial flora and induce satiety. Especially, plenty of high‐quality dietary fiber such as β‐glucan can reduce blood cholesterol, prevent diabetes, and improve immunity (Xiao et al., 2020b). Barley contains seven essential amino acids that can satisfy the daily needs of humans.…”

“…The natural structure of whole grains is modified and transformed through microbial fermentation process to enrich the part of effective active compounds and function properties (Xiao et al., 2020b). The process of microbial fermentation is an important part of the biological manufacturing field for modern biological engineering research.…”

“…The natural structure of whole grains is modified and transformed through microbial fermentation process to enrich the part of effective active compounds and function properties (Xiao et al, 2020b).…”

“…Especially, plenty of high-quality dietary fiber such as β-glucan can reduce blood cholesterol, prevent diabetes, and improve immunity (Xiao et al, 2020b). Barley contains seven essential amino acids that can satisfy the daily needs of humans.…”

Polysaccharides from Volvariella volvacea inhibit fat accumulation in C. elegans dependent on the aak‐2/nhr‐49‐mediated pathway

“…Subsequently, worms were washed with M9 to remove the extra dye, then imaged with a microscope (Leica, Wetzlar). The ORO intensities were quantified by Image J (Xiao et al., 2020c).…”