Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats

Abstract

Collagen has been considered a key treatment option in preventing damage to the articular cartilage over time and supporting the healing process, following the onset of osteoarthritis (OA). This study aimed to investigate the effect of collagen fermented from jellyfish (FJC) by Bacillus subtilis natto on anterior cruciate ligament transection with medial meniscectomy (ACLT + MMx)-induced knee OA in high-fat diet (HFD)-induced obesity in rats. The male Sprague–Dawley rats were fed an HFD for 6 weeks before ACLT + MMx surgery, after which they were administered a daily oral gavage of saline (control, OA, and OBOA), either with FJC (20 mg/kg, 40 mg/kg, and 100 mg/kg body weight) or glucosamine sulfate as a positive control (GS; 200 mg/kg body weight) for 6 weeks. Treatment with FJC decreased the fat weight, triglyceride, and total cholesterol levels in obese rats. Additionally, FJC downregulated the expression of some proinflammatory cytokines, including tumor necrosis factor-α, cyclooxygenase-2, and nitric oxide; suppressed leptin and adiponectin expression; and attenuated cartilage degradation. It also decreased the activities of matrix metalloproteinase (MMP)-1 and MMP-3. These results demonstrated that FJC showed a protective effect on articular cartilage and also suppressed the degradation of cartilage in an animal OA model, suggesting its potential efficacy as a promising candidate for OA treatment.

Protective effect of marine animals hydrolysis-peptides on adjuvant-induced arthritis in mice by gut microbiota and SCFAs

“…Apostichopus japonicus and Acaudina leucoprocta as two common species of sea cucumber with demonstrated health benefits for humans [22,23]. Phascolosoma esculenta, a marine epibenthos, is a favorable source of anti-oxidant, immune-modulatory and anti-inflammatory biological active peptides [24,25]. Another marine animal Rhopilema esculentum has also demonstrated antioxidant [26], anti-hypertension [27], and neurotoxic effects [28].…”

The unpredictability of scyphozoan jellyfish blooms

“…In eutrophication processes, jellyfish have been linked to the maintenance of water quality through top-down control of the food web (Peŕez-Ruzafa et al, 2002;Fernańdez-Alıás et al, 2022;, and their use as food has led to the emergence of a fishing and aquaculture industry focused on these organisms (Hsieh et al, 2001;Omori and Nakano, 2001;Purcell et al, 2007;Nishikawa et al, 2015;Khong et al, 2016;Leone et al, 2019). In addition, jellyfish are being studied in search of biomolecules with potential applications in pharmacology and medicine (Zimmer, 2005;Sugahara et al, 2006;De Rinaldis et al, 2021;De Domenico et al, 2023;Sudirman et al, 2023), and as the most energetically efficient swimmers, jellyfish biomechanics are a subject of study in the development of remotely operated swimming vehicles (Gemmell et al, 2013;Gemmell et al, 2015;Costello et al, 2021;Gemmell et al, 2021).…”