Fermented lily bulbs by “Jiangshui” probiotics improves lung health in mice

Khan, Aman; Wang, Weidong; Ji, Jing; Ling, Zhenmin; Liu, Pu; Xiao, Sa; Han, Huawen; Salama, El-Sayed; Kumar Khanal, Samir; Li, Xiangkai

doi:10.1016/j.foodchem.2023.138270

Food Chemistry

2024

DOI: 10.1016/j.foodchem.2023.138270

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Fermented lily bulbs by “Jiangshui” probiotics improves lung health in mice

Aman Khan,

Weidong Wang,

Jing Ji

et al.

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2024

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Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

Zhang,

Li,

Sun

et al. 2024

Mediators of Inflammation

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Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little is known about the regulatory effect of lung Lactobacillus and its mechanism in BPD. This study explored the effect of L. reuteri on hyperoxia‐induced mice lung injuries and examined whether L. reuteri played a role via the IL‐22/STAT3 pathway. We found that the intranasal administration of L. reuteri and its tryptophan metabolite indole‐3‐aldehyde (3‐IAld) ameliorated hyperoxia‐induced mice lung BPD‐like changes, deceased proinflammatory cytokines (IL‐1β, IL‐6, and TNF‐α), and increased the levels of surfactant‐associated protein C (SPC), aquaporin 5 (AQP5), and vascular endothelial growth factor receptor 2 (VEGFR2, also known as FLK‐1). Furthermore, L. reuteri and 3‐IAld increased the expression of IL‐22. IL‐22 was also confirmed to ameliorate hyperoxia‐induced mice lung pathological changes, and the protective effects of L. reuteri could be inhibited by anti‐IL‐22 neutralizing antibody. Finally, we confirmed STAT3 activation by IL‐22 in MLE‐12 cells. In summary, our study confirmed L. reuteri alleviated hyperoxia‐induced lung BPD‐like changes in mice by activating the IL‐22/STAT3 signaling pathway via IL‐22 production. Probiotics Lactobacillus is a potential treatment for hyperoxia‐induced lung injury in newborns.

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Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

Zhang,

Li,

Sun

et al. 2024

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

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Fermented lily bulbs by “Jiangshui” probiotics improves lung health in mice

Cited by 1 publication

References 32 publications

Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

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