Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection

Abstract

Background:Lactobacillus paracasei and Glycyrrhiza glabra have been reported as having beneficial effects on Helicobacter pylori infection. We aimed to assess the efficacy and safety of fermented milk containing L paracasei HP7 and G glabra in patients with H pylori infection.Methods:This multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial was conducted in 2 hospitals from April to December 2017. Patients with H pylori infection were randomized into either the treatment group (fermented milk with L paracasei HP7 and G glabra) or placebo group (fermented milk only) once daily for 8 weeks. The primary endpoint was the gastric load of H pylori measured by 13C-urea breath test (UBT). Secondary endpoints were histologic and clinical improvement.Results:A total of 142 patients were randomly allocated to the treatment (n = 71) or placebo groups (n = 71). Compared to baseline data, the quantitative value of 13C-UBT at 8 weeks was significantly reduced in the treatment group (from 20.8 ± 13.2% to 16.9 ± 10.8%, P = .035), but not in the placebo group (P = .130). Chronic inflammation improved significantly only in the treatment group (P = .013), whereas the neutrophil activity deteriorated significantly only in the placebo group (P = .003). Moreover, the treatment group had significant improvement in gastrointestinal symptoms (P = .049) and quality of life (P = .029). No serious adverse events were observed.Conclusion:The combination of fermented milk containing L paracasei and G glabra reduced H pylori density and improved histologic inflammation. However, their mechanisms of action should be elucidated in further studies.

Lactobacillus paracasei S16 Alleviates Lumbar Disc Herniation by Modulating Inflammation Response and Gut Microbiota

“…Recent studies have shown that the Lactobacillus paracasei ( L. paracasei ) treatment can alleviate inflammation-related disorders by modulating the production of anti- and pro-inflammatory cytokines ( 9 , 10 ). Furthermore, clinical studies also revealed the important role of L. paracasei supplementation in ameliorating inflammation in humans ( 11 , 12 ). Mechanically, L. paracasei can act as a probiotic to improve gut microbial composition ( 13 , 14 ).…”

Evaluation of Growth, Viability, Lactic Acid Production and Anti-Infective Effects of Lacticaseibacillus rhamnosus ATCC 9595 in Bacuri Juice (Platonia insignis)

“…Functional foods containing probiotics have been demonstrating effectiveness to prevent or treat health problems, including digestive disorders, such as irritable bowel syndrome and necrotizing enterocolitis [ 1 , 2 , 3 ]. In particular, those formulations containing lactobacilli are recognized for their ability to modulate the human microbiota and induce anti-inflammatory and anti-oxidant effects [ 4 , 5 , 6 ].…”

“…Probiotics are commonly found in dairy foods, such as milks, yogurts and cheeses [ 4 , 7 , 8 ]; however, fruit juices may also be excellent vehicles for development of probiotic products due to their nutritional properties and presence of bioactive compounds (vitamins, phenolic acids, flavonoids and other anti-oxidant compounds) [ 9 , 10 , 11 ]. The use of fruit juices containing probiotics also gives opportunities to individuals with specific conditions (lactose intolerance, allergy to milk components and vegetarians) to benefit from the consumption of these bacteria [ 12 , 13 ].…”

Probiotics as Potential Antimicrobials for the Treatment of Infections: Current Reality or Remote Future?

“…However, antibiotic therapy promotes an imbalance in the intestinal microbiota and increased levels of resistant bacteria [110], as well as species associated with persistent gastric inflammation and gastric carcinogenesis [111]. This situation justifies probiotic supplementation, aiming to reduce undesirable changes in the intestinal microbiota, promote the eradication of H. pylori [108,112], produce significant improvements in gastrointestinal symptoms, and, consequently, in the quality of life of individuals [108,109]. The combination of probiotics with antibiotic therapy for the eradication of H. pylori was suggested in the Thailand Consensus, held in 2015 [110].…”