Fermented milk for hypertension

Usinger, Lotte; Reimer, Christina; Ibsen, Hans

doi:10.1002/14651858.cd008118.pub2

Cited by 18 publications

(11 citation statements)

References 43 publications

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“…In order to assess the associations of dairy products with cardio-metabolic diseases, we consequently focused on meta-analyses that combined the results of either observational studies [ 8 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ] as well as two summarizing systematic reviews [ 42 , 43 ]. In addition, one meta-analysis of randomized clinical trials (RCTs) evaluating the effects of fermented dairy products on hypertension was published by Usinger et al [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Fermented Food and Non-Communicable Chronic Diseases: A Review

et al. 2018

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Fermented foods represent a significant fraction of human diets. Although their impact on health is positively perceived, an objective evaluation is still missing. We have, therefore, reviewed meta-analyses of randomized controlled trials (RCT) investigating the relationship between fermented foods and non-transmissible chronic diseases. Overall, after summarizing 25 prospective studies on dairy products, the association of fermented dairy with cancer was found to be neutral, whereas it was weakly beneficial, though inconsistent, for specific aspects of cardio-metabolic health, in particular stroke and cheese intake. The strongest evidence for a beneficial effect was for yoghurt on risk factors of type 2 diabetes. Although mechanisms explaining this association have not been validated, an increased bioavailability of insulinotropic amino acids and peptides as well as the bacterial biosynthesis of vitamins, in particular vitamin K2, might contribute to this beneficial effect. However, the heterogeneity in the design of the studies and the investigated foods impedes a definitive assessment of these associations. The literature on fermented plants is characterized by a wealth of in vitro data, whose positive results are not corroborated in humans due to the absence of RCTs. Finally, none of the RCTs were specifically designed to address the impact of food fermentation on health. This question should be addressed in future human studies.

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Section: Resultsmentioning

confidence: 99%

Fermented Food and Non-Communicable Chronic Diseases: A Review

et al. 2018

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“…We screened 493 reviews after removal of duplicates. Based on their titles and abstracts, a total of 82 reviews met the inclusion criteria and made up the data set 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 . The 82 relevant CSRs included 1177 RCTs.…”

Section: Resultsmentioning

confidence: 99%

An assessment of randomized controlled trials (RCTs) for non-communicable diseases (NCDs): more and higher quality research is required in less developed countries

Hong

2015

Sci Rep

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Research is crucial to implement evidence-based health interventions for control of non-communicable diseases (NCDs). This study aims to assess main features of randomized controlled trials (RCTs) for control of NCDs, and to identify gaps in clinical research on NCDs between high-income and less developed countries. The study included 1177 RCTs in 82 Cochrane Systematic reviews (CSRs) and evaluated interventions for adults with hypertension, diabetes, stroke, or heart diseases. Multivariate logistic regression analyses were conducted to explore factors associated with risk of bias in included RCTs. We found that 78.2% of RCTs of interventions for major NCDs recruited patients in high-income countries. The number of RCTs included in the CSRs was increasing over time, and the increasing speed was more noticeable for RCTs conducted in middle-income countries. RCTs conducted in less developed countries tended to be more recently published, less likely to be published in English, with smaller sample sizes, and at a higher risk of bias. In conclusion, there is still a lack of research evidence for control of NCDs in less developed countries. To brace for rising NCDs and avoid waste of scarce research resources, not only more but also higher quality clinical trials are required in low-and-middle-income countries.

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“…The study also found that the LTP-induced hypotensive effects were not related to subject age, baseline BP value, administered dose or length of treatment [119]. Conflicting results however, were reported in a recent meta-analysis by Usinger et al [132]. Data from 15 controlled trials (1232 subjects in total) that observed the effect of fermented milk or similar products produced by Lactobacilli fermentation of milk proteins were used in the metaanalysis.…”

Section: Human Studiesmentioning

confidence: 95%