Fermented Wheat Aleurone Enriched With Probiotic Strains LGG and Bb12 Modulates Markers of Tumor Progression in Human Colon Cells

Borowicki, Anke; Michelmann, Anke; Stein, Katrin; Scharlau, Daniel; Scheu, Kerstin; Obst, Ursula; Glei, Michael

doi:10.1080/01635581.2010.516874

Cited by 33 publications

(29 citation statements)

References 41 publications

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“…These results are in line with former studies which revealed induction of apoptosis in LT97 cells by FS obtained from different raw nut varieties including macadamia nuts [18], or other dietary fiber sources producing butyrate as fermentation end product [29,30,38]. Again, no direct impact of different roasting conditions on apoptotic potential of fermented macadamia nuts could be observed in the present study.…”

Section: Discussionsupporting

confidence: 82%

Influence of roasting on the chemopreventive potential of macadamia nuts

Schlörmann¹,

Dinc²,

Lorkowski³

et al. 2017

SDRP-JFST

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Background: Due to their content of dietar y fiber , the consumption of macadamia nuts may help to reduce the risk for colon cancer development. Methods: To examine potential chemopr eventive effects of macadamia nuts and to study the influence of different roasting conditions (R), raw and roasted macadamia nuts (R1=138.9°C/25 min, R2=160.1°C/15 min and R3=170.7°C/13 min) were subjected to in vitro digestion and fermentation. LT97 colon adenoma cells were incubated with fermentation supernatants (FS) and cell growth and apoptosis as well as gene expression of CAT, SOD2, GPx1 and GSTP1 were examined. Results: Macadamia nut FS decr eased the gr owth of adenoma cells in a time-and dose-dependent manner. FS obtained from macadamia nuts significantly increased caspase-3 activity (up to 3.8-fold), particularly at a concentration of 5% in comparison to the respective blank control. In particular, FS obtained from raw macadamia nuts increased mRNA levels of SOD2 (up to 1.6-fold) and GSTP1 (up to 1.9-fold) in comparison to the fermentation blank control. The roasting process had no direct impact on the mentioned effects. Conclusion:The pr esent study indicates that macadamia nuts exhibit chemopreventive effects regarding the risk for colon cancer development which are largely unaffected by the state of roasting.

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Section: Discussionsupporting

confidence: 82%

Influence of roasting on the chemopreventive potential of macadamia nuts

Schlörmann¹,

Dinc²,

Lorkowski³

et al. 2017

SDRP-JFST

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“…has been shown to kill CRC cells through apoptosis in vitro via its metabolites, the SCFA, acetate and propionate [93,94]. However, synbiotics would be more active than probiotics alone in increasing the production of SCFA and consequently protect against CRC onset [10,95]. A possible explanation is that the interaction of the immunomodulating properties of probiotic bacteria and butyrate, which is more produced via fermentation of prebiotics, results in an upregulation of apoptosis [10,11].…”

Section: Discussionmentioning

confidence: 99%

Potential role of probiotics on colorectal cancer prevention

et al. 2012

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BackgroundColorectal cancer represents the most common malignancy of the gastrointestinal tract. Owing to differences in dietary habits and lifestyle, this neoplasm is more common in industrialized countries than in developing ones. Evidence from a wide range of sources supports the assumption that the link between diet and colorectal cancer may be due to an imbalance of the intestinal microflora.DiscussionProbiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host, and they have been investigated for their protective anti-tumor effects. In vivo and molecular studies have displayed encouraging findings that support a role of probiotics in colorectal cancer prevention.SummarySeveral mechanisms could explain the preventive action of probiotics against colorectal cancer onset. They include: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; anti-proliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase signaling pathways.

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“…Open Access Scan to access more free content compounds, [27][28][29][30][31][32][33][34][35] competition with putrefactive and pathogenic microbiota, [36][37][38][39][40] improvement of the host's immune response, [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] enhancement of natural killer cell cytotoxicity 56 and inhibition of interleukin (IL) 6 production in the colonic mucosa 57 counteracting cancer development by antiproliferative effects 58 via regulation of apoptosis and cell differentiation, [59][60][61][62][63][64][65][66][67] fermentation of undigested food [68][69][70][71][72][73] and inhibition of tyrosine kinase signalling pathways. 74…”

Section: Experimental Evidence Adhesion To the Gastrointestinal Mucosamentioning

confidence: 99%

Mechanisms and therapeutic effectiveness of lactobacilli

et al. 2015

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The gut microbiome is not a silent ecosystem but exerts several physiological and immunological functions. For many decades, lactobacilli have been used as an effective therapy for treatment of several pathological conditions displaying an overall positive safety profile. This review summarises the mechanisms and clinical evidence supporting therapeutic efficacy of lactobacilli. We searched Pubmed/Medline using the keyword ‘Lactobacillus’. Selected papers from 1950 to 2015 were chosen on the basis of their content. Relevant clinical and experimental articles using lactobacilli as therapeutic agents have been included. Applications of lactobacilli include kidney support for renal insufficiency, pancreas health, management of metabolic imbalance, and cancer treatment and prevention. In vitro and in vivo investigations have shown that prolonged lactobacilli administration induces qualitative and quantitative modifications in the human gastrointestinal microbial ecosystem with encouraging perspectives in counteracting pathology-associated physiological and immunological changes. Few studies have highlighted the risk of translocation with subsequent sepsis and bacteraemia following probiotic administration but there is still a lack of investigations on the dose effect of these compounds. Great care is thus required in the choice of the proper Lactobacillus species, their genetic stability and the translocation risk, mainly related to inflammatory disease-induced gut mucosa enhanced permeability. Finally, we need to determine the adequate amount of bacteria to be delivered in order to achieve the best clinical efficacy decreasing the risk of side effects.

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Fermented Wheat Aleurone Enriched With Probiotic Strains LGG and Bb12 Modulates Markers of Tumor Progression in Human Colon Cells

Cited by 33 publications

References 41 publications

Influence of roasting on the chemopreventive potential of macadamia nuts

Influence of roasting on the chemopreventive potential of macadamia nuts

Potential role of probiotics on colorectal cancer prevention

Mechanisms and therapeutic effectiveness of lactobacilli

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