We examine contributions to single Higgs boson production processes via Z and W bosons in the SU (3) C × SO(5) W × U (1) X gauge-Higgs unification (GHU) model. In particular, we analyze the cross sections of three single Higgs boson production processes e − e + → Zh, e − e + → ν νh, and e − e + → e − e + h in the SM and the GHU model. For the Higgs strahlung process e − e + → Zh, we show that for a parameter region satisfying the current experimental constraints, a maximum deviation from the SM is about up to 6% for the center-of-mass energy of the initial electron and positron √ s = 250 GeV and that from the SM is about up to 20% for √ s = 500 GeV, depending on the initial polarization of electron and positron. The deviation from the SM is monotonically increasing with respect to √ s for √ s 1 TeV. By using the Higgs strahlung process, it is possible to explore up to the region of tens of TeV in terms of the Kaluza-Klein (KK) mass. We also show that the sign of the bulk mass of a lepton multiplet in the GHU model can be determined by examining the deviation of the left-right symmetry of the e − e + → Zh process from the SM. The contributions to the cross sections of the e − e + → ν νh and e − e + → e − e + h processes via the Z and W bosons are relatively small compared to that for e − e + → Zh at least for √ s ≤ 1 TeV. As is the same as in the SM, the e − e + → ν νh process gives a main contribution to the single Higgs boson production processes for √ s 500 GeV, but large deviations from the SM are only observed on energy scales close to the masses of the first KK gauge bosons or higher.