Ferret Lymphoma: The Old and the New

Hess, Laurie

doi:10.1016/j.saep.2005.06.005

Cited by 11 publications

(12 citation statements)

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“…5,6,18 Diagnosis of lymphoma is usually based on history, clinical signs, and results of clinicopathologic tests, radiography, ultrasonography, and cytologic and histologic evaluation of tissue and fluid samples. 5,19 Results of clinicopathologic testing can vary depending on the involved organ system, but mild nonregenerative anemia and concurrent adrenocortical disorder are the most common findings in ferrets, 3,5 as was also detected in the ferret of this report. Imaging can aid in the overall assessment of a patient, lesion localization, acquisition of representative diagnostic samples, and treatment follow-up.…”

Section: Discussionmentioning

confidence: 56%

Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret

Eshar

Wyre²,

Griessmayr³

et al. 2010

javma

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Section: Discussionmentioning

confidence: 56%

Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret

Eshar

Wyre²,

Griessmayr³

et al. 2010

javma

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“…12 Lymphoma is the most common malignant neoplasm in the ferret. 13,21,38 In order to classify the specific type of GI lymphoma in ferrets, as in other species, further immunophenotyping diagnostics, such as immunohistochemistry (IHC), are often performed. Immunophenotyping of lymphoma in ferrets shows a predominance of T-cell lymphomas in the GI tract.…”

Section: Introductionmentioning

confidence: 99%

Histology and immunohistochemistry of severe inflammatory bowel disease versus lymphoma in the ferret (Mustela putorius furo)

et al. 2016

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Inflammatory bowel disease (IBD) is a common disorder of ferrets (Mustela putorius furo) that may progress to lymphoma. Although routine histology is used to distinguish between these diseases, misclassifications may occur. Immunohistochemistry (IHC) is commonly used to distinguish between IBD and lymphoma in small animals. The objective of our study was to determine the agreement in the diagnosis reached solely using hematoxylin and eosin (HE)-stained, full-thickness sections versus using a combination of HE and IHC. Enteric sections from 44 ferrets previously diagnosed with IBD or intestinal lymphoma and 3 control ferrets were analyzed by pathologists with expertise in ferrets. A pathologist blinded to the original diagnosis assessed the same HE-stained sections. Analysis was then repeated using HE sections in parallel with sections stained using antibodies against CD3 and CD79a. No significant difference was found between the original HE diagnosis and the HE diagnosis reached by the blinded pathologist (p = 0.91) or between the blinded pathologist's HE versus HE with IHC diagnosis (p = 0.16). In the 2 cases where disagreement was present, IHC was pivotal in reaching a final diagnosis. There was no significant age (p = 0.29) difference between diagnoses; however, significantly more male ferrets were affected with IBD than females (p = 0.004). Immunophenotype of the lymphoma was not correlated with predilection for location in the intestinal wall (p = 0.44). Results suggest that although IHC is not necessary to distinguish IBD from intestinal lymphoma in ferrets, it can be useful a definitive diagnosis in cases of severe IBD.

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“…L ymphoma is the most common malignant neoplasia in domestic ferrets, Mustela putorius furo . Following insulinoma and adrenocortical neoplasia, it is the third most common neoplasia of domestic ferrets overall . In ferrets, lymphoma can be classified based on tissue involvement, including multicentric, mediastinal, gastrointestinal, cutaneous, and extranodal .…”

Section: Introductionmentioning

confidence: 99%

“…Following insulinoma and adrenocortical neoplasia, it is the third most common neoplasia of domestic ferrets overall . In ferrets, lymphoma can be classified based on tissue involvement, including multicentric, mediastinal, gastrointestinal, cutaneous, and extranodal . The presentation and organ distribution of lymphoma has been associated with the age of onset .…”

Section: Introductionmentioning

confidence: 99%

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IMAGING FINDINGS IN 14 DOMESTIC FERRETS (MUSTELA PUTORIUS FURO) WITH LYMPHOMA

Suran

Wyre

2013

Vet Radiology Ultrasound

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Lymphoma is the most common malignant neoplasia in domestic ferrets, Mustela putorius furo. However, imaging findings in ferrets with lymphoma have primarily been described in single case reports. The purpose of this retrospective study was to describe imaging findings in a group of ferrets with confirmed lymphoma. Medical records were searched between 2002 and 2012. A total of 14 ferrets were included. Radiographs (n = 12), ultrasound (n = 14), computed tomography (CT; n = 1), and magnetic resonance imaging (MRI; n = 1) images were available for review. Median age at the time of diagnosis was 5.2 years (range 3.25-7.6 years). Clinical signs were predominantly nonspecific (8/14). The time between the first imaging study and lymphoma diagnosis was 1 day or less in most ferrets (12). Imaging lesions were predominantly detected in the abdomen, and most frequently included intra-abdominal lymphadenopathy (12/14), splenomegaly (8/14), and peritoneal effusion (11/14). Lymphadenopathy and mass lesions were typically hypoechoic on ultrasound. Mild peritoneal effusion was the only detected abnormality in two ferrets. Mild pleural effusion was the most common thoracic abnormality (3/12). Expansile lytic lesions were present in the vertebrae of two ferrets with T3-L3 myelopathy and the femur in a ferret with lameness. Hyperattenuating, enhancing masses with secondary spinal cord compression were associated with vertebral lysis in CT images of one ferret. The MRI study in one ferret with myelopathy was inconclusive. Findings indicated that imaging characteristics of lymphoma in ferrets are similar to those previously reported in dogs, cats, and humans.

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Ferret Lymphoma: The Old and the New

Cited by 11 publications

References 0 publications

Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret

Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret

Histology and immunohistochemistry of severe inflammatory bowel disease versus lymphoma in the ferret (Mustela putorius furo)

IMAGING FINDINGS IN 14 DOMESTIC FERRETS (MUSTELA PUTORIUS FURO) WITH LYMPHOMA

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