Ferrihaemoglobinaemia (methaemoglobinaemia) in man and the horse

Ramsay, W. N. M.

doi:10.1042/bj0380470

Cited by 13 publications

(3 citation statements)

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“…As co‐oximetry is performed in‐vitro many of the sources of interference with pulse oximetry are eliminated (Moyle 2002). Co‐oximetry is also preferable to calculation of oxyhaemoglobin saturation from PaO 2 measurement and the oxyhaemoglobin dissociation curve, as it allows for the variable levels of methaemoglobin in normal animals (Ramsay 1944; Smith & Beutler 1966; Ralston et al. 1991).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Masimo signal extraction technology pulse oximetry in anaesthetized pregnant sheep

Quinn

Raisis

Musk

2013

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Evaluation of Masimo signal extraction technology pulse oximetry in anaesthetized pregnant sheep

Quinn

Raisis

Musk

2013

Veterinary Anaesthesia and Analgesia

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“…The haemoglobin solutions were, if possible, used within 30 hr of the withdrawal from the blood; if longer periods were allowed to elapse some irreversible disappearance of CO was found to occur, the nature of which was not determined, but may in part be due to slow increases in the gas. combining capacity of the haemoglobin (Roughton, Darling & Root, 1944;Ramsay, 1944). If, however, the haemoglobin was kept saturated with CO at 1 atm pressure from an early stage, it could be used for periods up to 4 days without this trouble arising.…”

Section: Preparation Of Haemoglobin 8olutionsmentioning

confidence: 99%

“…combining capacity of the haemoglobin (Roughton, Darling & Root, 1944;Ramsay, 1944). If, however, the haemoglobin was kept saturated with CO at 1 atm pressure from an early stage, it could be used for periods up to 4 days without this trouble arising.…”

Section: Preparation Of Haemoglobin 8olutionsmentioning

confidence: 99%

The diffusion coefficients of carbon monoxide and nitrogen in haemoglobin solutions

Longmuir¹,

Roughton²

1952

The Journal of Physiology

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Krogh's (1919a) measurements of the rate of diffusion of 02, N2, CO and CO02 through animal tissues have formed the basis of many calculations of the role of diffusion in physiological processes (see, for example, Krogh, 1919b;Hill, 1928;Roughton, 1932;Jacobs, 1935). No information, however, appears to exist as to the rate of diffusion of these dissolved gases through homogeneous solutions of proteins: the value of the diffusion coefficients of 02 and CO in concentrated haemoglobin solutions has, in particular, been a desideratum in the theoretical investigations of Roughton (1932) and Nicolson & Roughton (1951) on the rate of exchange of 02 and CO between the interior of the red blood cells and the surrounding fluid. At the concentrations found in the red cells, the haemoglobin molecules must, according to Perutz (1948), be practically touching and there should accordingly be both marked geometrical obstruction and viscous resistance to the passage of small molecules of dissolved gases between the large protein molecules. The relation between the value of the diffusion coefficients and the protein concentration is therefore also of some theoretical interest.In the present paper we have determined the diffusion coefficients of N2 and CO in haemoglobin solutions ranging from 0 to 45 g haemoglobin/100 ml., the latter concentration being appreciably higher than that usually found in the red cells. In the case of N2 there has been no complication from any simultaneous chemical reactions of the penetrating substance: with CO, on the other hand, there has, from time to time, been trouble from side reactions even when the concentrations of CO have been such as to ensure that the haemoglobin is at least 99.99 % saturated with CO. Fortunately for our present purpose, N2 and CO have the same molecular weight and are very similar in many of their physical properties, including solubility. A priori, their diffusion coefficients in haemoglobin solutions should be about the same: molecules has also to be taken into account. Perutz's work would appear to make the need for such an allowance very unlikely, but fortunately we have found it possible, by means of an alternative method to our main one of measuring the diffusion coefficients of CO in haemoglobin solutions, to obtain direct experimental evidence on this point. METHODS I. Diffusion apparatusIn most of the experiments diffusion was measured between a gas phase containing CO or N2 at 1 atm pressure, and haemoglobin solution containing these gases in solution, but at different partial pressures from those in the gas phase. The apparatus, which was specially designed for use in conjunction with the Van Slyke gasometric methods, is shown in Fig. 1. It consists essentially of a large glass tap, T (bore about 1 cm), one lead of which is closed at the end whilst the other is fused to a straight capillary bore tap, U, and also to a 3-way capillary bore tap, V, the 265 266 I. S. LONGMUIR AND F. J. W. ROUGHTON leads from which are inclined at angles of 1200 to each other. On the...

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Methemoglobin Values in Premature and Mature Infants and Children

Kravitz¹

1956

Arch Pediatr Adolesc Med

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Ferrihaemoglobinaemia (methaemoglobinaemia) in man and the horse

Cited by 13 publications

References 2 publications

Evaluation of Masimo signal extraction technology pulse oximetry in anaesthetized pregnant sheep

Evaluation of Masimo signal extraction technology pulse oximetry in anaesthetized pregnant sheep

The diffusion coefficients of carbon monoxide and nitrogen in haemoglobin solutions

Methemoglobin Values in Premature and Mature Infants and Children

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