Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity

Zhang, Junfeng; Cao, Jiajia; Xu, Hui; Dong, Guanping; Huang, Ke; Wu, Wei; Ye, Jingjing; Fu, Junfen

doi:10.1002/jcla.23602

Cited by 11 publications

(14 citation statements)

References 33 publications

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“…Previously, the correlation of serum ferritin and NAFLD has been incompletely studied in children. Ferritin levels in children with NAFLD were obviously higher than their counterparts in non‐NAFLD group 24 . A recent study by H.B.…”

Section: Discussionmentioning

confidence: 80%

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The association between non‐alcoholic fatty liver disease and serum ferritin levels in American adults

Yang

Cao

et al. 2022

Clinical Laboratory Analysis

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Background Elevated serum ferritin levels (SFLs) was previously reported to be related with hepatic histologic severity and advanced liver fibrosis among non‐alcoholic fatty liver disease (NAFLD) patients. However, whether NAFLD influences SFLs remains uncertain and needs more clinical evidences. This study explored the differences of SFLs in US adults with or without NAFLD. Methods We conducted a cross‐sectional study of 3689 participants aged 18–80 years using the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle. NAFLD status was confirmed based on controlled attenuation parameter (CAP) values ≥274 dB/m through vibration controlled and transient elastography (VCTE). We performed weighted multivariable logistic regression models to evaluate the associations between NAFLD and SFLs in different age and gender. Results There was a positive association between NAFLD and SFLs in all three models (model 1:β = 23.07, 95% CI: 10.32, 35.81; model 2:β = 23.68, 95% CI: 10.86, 36.50; model 3:β = 13.86, 95% CI: 0.29, 27.43). After adjusting for the covariates, this positive association persisted in females (β = 16.22, 95% CI: 2.81, 29.62). Further, relationships between NAFLD and SFLs were significantly different in various age groups. In the subgroup stratified by gender, their associations further differed. In males, the positive association was more prominent in 50–64 age group (β = 70.89, 95% CI: 25.14, 116.64). In females, this positive association was more prominent in 18–34 age group (β = 20.72, 95% CI: 7.45, 33.99). However, no correlations between severe steatosis, significant fibrosis, advanced fibrosis, cirrhosis, and SFLs in adults with NAFLD were found. Conclusion This study indicated that US adults suffered with NAFLD had significantly higher SFLs compared with their counterparts in non‐NAFLD group. Moreover, the associations between NAFLD and SFLs further differed by age and gender.

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Section: Discussionmentioning

confidence: 80%

“…Ferritin levels in children with NAFLD were obviously higher than their counterparts in non‐NAFLD group. 24 A recent study by H.B. Kim et al 25 found serum ferritin level were positively associated with NAFLD in postmenopausal women.…”

Section: Discussionmentioning

confidence: 96%

The association between non‐alcoholic fatty liver disease and serum ferritin levels in American adults

Yang

Cao

et al. 2022

Clinical Laboratory Analysis

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“…Another cross-sectional study conducted in Guangzhou, China, found that among children with obesity attributed to BMI, ferritin levels in the dyslipidemia group were higher than those in the healthy fat group [ 35 ]. Other studies have also shown that ferritin is an independent risk factor for nonalcoholic fatty liver in children with obesity and in adolescents [ 36 , 37 ]. These findings suggested there is a synergistic effect of ferritin and obesity on abnormal lipid metabolism both in children and adults.…”

Section: Discussionmentioning

confidence: 99%

Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents

Wang

Zhu

et al. 2022

IJERPH

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Objective: This study examined the association between serum ferritin and dyslipidemia in children and adolescents with different degrees of obesity. Method: In this multi-stage, stratified, randomized, sampling cross-section cohort study, demographic data were collected by questionnaire from 4320 children and adolescents (aged 6–17 years) in Shanghai, China. Anthropometric measures and percent body fat (PBF) were recorded. Serum lipid parameters were detected by an automatic biochemical method, and ferritin levels were measured by an automatic immunoassay. Results: Our results showed 70.6%, 13.9%, and 15.5% of participants had a healthy body fat, low fat, and overweight/obese, respectively. Increasing ferritin quartiles were independently associated with a greater hazard of dyslipidemia, especially in overweight/obese participants, and the OR (95% CI) was 3.01 (1.29–7.00), 3.58 (1.59–8.04), and 5.66 (2.57–12.46) across the ferritin quartiles after adjustment for confounders. Ferritin was only a predictive value for dyslipidemia in overweight/obese participants (AUC = 0.64) and was consistent in boys (AUC = 0.61) and girls (AUC = 0.68). The significant positive correlation between ferritin value and lipid abnormalities profiles (except for low HDL-C) mainly appeared in the overweight/obesity group. Conclusion: The results showed that serum ferritin can be considered an independent risk factor for dyslipidemia in children and adolescents with obesity. Highlights: Ferritin overload had a greater risk of dyslipidemia, especially in children and adolescents with overweight/obesity.

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“…NAFLD was defined based on hepatic ultrasound, which was conducted to assess the presence and extent of hepatic steatosis according to the following guidelines: (a) a diffuse hyperechoic texture (bright liver); (b) increased liver echo texture compared to the kidney; (c) deep beam attenuation; (d) vascular blurring (absence of normal echogenic walls of the portal veins and hepatic veins). Exclusion criteria were: drugs and genetic metabolic liver disease, history of severe heart, liver, and kidney disease, type 1 diabetes mellitus, malignancy, pituitary disease, hyperprolactinemia, viral hepatitis; previous drinking history, and other related endocrine and metabolic diseases [12]. The study was approved by the Ethics Committee of Shaoxing Maternity and Child Health Care Hospital (No.…”

Section: Study Populationmentioning

confidence: 99%

Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in Obese Children

et al. 2023

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This study investigates whether serum prolactin (PRL) is a key factor for nonalcoholic fatty liver disease (NAFLD) in children. A total of 691 obese childred participated in this study and were divided into a NAFLD group (n=366) and simple obesity (SOB) group (n=325) according to the hepatic ultrasound results. The two groups were matched for gender, age, pubertal development, and body mass index (BMI). All patients underwent an OGTT test, and fasting blood samples were collected to measure prolactin. Stepwise logistic regression was performed to identify significant predictors of NAFLD. Serum prolactin levels were significantly lower in NAFLD subjects than in the SOB subjects [82.4 (56.36, 118.70) vs. 99.78 (63.89, 153.82), p<0.001] (mIU/l). NAFLD was strongly associated with insulin resistance (HOMA-IR) and prolactin, with lower levels of prolactin increasing the risk of NAFLD (adjusted ORs = 1.741; 95% CI: 1.059–2.860) across the prolactin concentration tertiles after adjustment for confounders. Low serum prolactin levels are associated with the presence of NAFLD; thus, increased circulating prolactin might be a compensatory response for obesity in children.

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Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity

Cited by 11 publications

References 33 publications

The association between non‐alcoholic fatty liver disease and serum ferritin levels in American adults

The association between non‐alcoholic fatty liver disease and serum ferritin levels in American adults

Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents

Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in Obese Children

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