2023
DOI: 10.1515/mr-2023-0001
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Ferritin-based nanomedicine for disease treatment

Abstract: Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanoca… Show more

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Cited by 8 publications
(3 citation statements)
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“…This targeted delivery approach may provide benefits such as improved drug accumulation at the site of action, controlled release, and protection against degradation. This assumes importance particularly given that human H ferritin‐based nanoparticles are currently in the preclinical phase for targeted cancer chemotherapy (Falvo et al, 2021 ) and undergoing clinical trials as a platform for the vaccine development (Zhu et al, 2023 ).…”
Section: Resultsmentioning
confidence: 99%
“…This targeted delivery approach may provide benefits such as improved drug accumulation at the site of action, controlled release, and protection against degradation. This assumes importance particularly given that human H ferritin‐based nanoparticles are currently in the preclinical phase for targeted cancer chemotherapy (Falvo et al, 2021 ) and undergoing clinical trials as a platform for the vaccine development (Zhu et al, 2023 ).…”
Section: Resultsmentioning
confidence: 99%
“…These subunits can self-assemble into a spherical hollow nanocage with an outer diameter of 12 nm and an inner cavity diameter of 8 nm [ 27 , 28 , 29 ]. In recent years, ferritin has been extensively employed as a nanocarrier in the development of various viral vaccines, including those for influenza virus, classical swine fever virus, human immunodeficiency virus, porcine rotavirus, and others [ 30 , 31 , 32 , 33 , 34 ]. However, there are few reports on the use of ferritin as a vector to develop PRRSV vaccines.…”
Section: Introductionmentioning
confidence: 99%
“…HFn consist of 24 monomers of the H-chain of Fn characterized by a high thermal stability and low immunogenicity, as already reported by different groups, including ours. [13][14][15] Moreover, HFn can be loaded with drugs and fluorescent dyes for theranostic applications, following different approaches. The most common ones are the disassembly-reassembly induced by pH variation or by incubation with urea, and the opening of peculiar loading channels by increasing the temperature of the HFn solution.…”
Section: Introductionmentioning
confidence: 99%