Ferritin im Serum – Ein ‘Tumormarker’ bei malignen Lymphomen?

Aulbert, E.; O, Steffens

doi:10.1159/000216735

Cited by 19 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IgD myeloma frequently have organ infiltrations of skin, lymph nodes, liver or spleen, and about 10% could follow a leukemic course [26], No association with histological subgroup was found in the present study, but the number of patients in each subgroup was small. This report shows that p2m is an excellent marker of response to treatment, as an overall agreement between p2m and clini cal outcome was observed in 26 of 29 cases [27,28]. Other in vestigators claim that in lymphoproliferative disorders, such as MM and low-grade NHL.…”

Section: Discussionsupporting

confidence: 56%

Serum β2-Microglobulin for Staging and Monitoring of Multiple Myelomas and Other Non-Hodgkin Lymphomas

Poley¹,

Fateh-Moghadam²,

Nüssler

et al. 1994

Oncol Res Treat

View full text Add to dashboard Cite

Background: In lymphoproliferative disorders serum β₂-microglobulin (β₂m) can be useful as a clinical marker. Material and Methods: β₂m measurements were carried out with a new assay of Hoffmann-La Roche, which is a one-step solid-phase enzyme immunoassay with competitive inhibition. Sera of 81 healthy subjects, 42 patients with renal failure, 108 patients with monoclonal gammopathies [3 monoclonal gammopathies of undetermined significance (MGUS), 91 multiple myeloma (MM), 14 macroglobulinemia (MG)], and 11 patients with non-Hodgkin lymphoma (NHL) were tested. In addition β₂m was determined during follow-up of 29 patients with myeloma and lymphoma. Results: β₂m values of normal sera ranged from 1.0 to 3.0 mg/l in 97.5%. Patients with renal malfunction had the highest β₂m concentrations (60 mg/l) with significant correlation (ρ < 0.01) to serum creatinine (r=0.45). 57% of the patients with MM and NHL had raised β₂m levels when compared to healthy controls. Serum β₂m values did not correlate with the serum levels of monoclonal immunoglobulins. Using the myeloma staging system of Durie and Salmon, a strong association of pretreatment serum β₂m with advanced stage of disease was found. In stages II and III, β₂m levels were significantly higher than in stage I (p < 0.001). Seven patients with smoldering myeloma showed β₂m concentrations within the normal range. No association with histologic cell types of myeloma was found. In the follow-up of patients with myeloma, β₂m values decreased with response to chemotherapy and were low in stable remission. At relapse very high β₂m concentrations were associated with a poor prognosis. Conclusion: Serum β₂m appears to be a good prognostic marker in MM independent of the paraprotein concentration. In MM and also in other NHL, β₂m determination helps to optimize therapy.

show abstract

Section: Discussionsupporting

confidence: 56%

Serum β2-Microglobulin for Staging and Monitoring of Multiple Myelomas and Other Non-Hodgkin Lymphomas

Poley¹,

Fateh-Moghadam²,

Nüssler

et al. 1994

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…Upon activation of the immune system, both B-and T-lymphocytes actively release ␤ 2 m into circulation where it is later eliminated via glomerular filtration and tubular reabsorption. Serum levels of ␤ 2 m have been measured and nominally correlated to ailments such as AIDS (1,2), rheumatoid arthritis (3), leukemia (4), myeloma (5), and malignant lymphoma (6). On the other hand, ␤ 2 m levels in urine are indicators of glomerular filtration rate and tubular reabsorption (7).…”

Section: ␤-2-microglobulin (␤ 2 M)mentioning

confidence: 99%

Detection and Quantification of β-2-Microglobulin Using Mass Spectrometric Immunoassay

Tubbs

Nedelkov

Nelson

2001

Analytical Biochemistry

View full text Add to dashboard Cite

“…Türkiye'de 65 yaş üstü nüfus 1980 nüfus sayımına göre nüfusun %4.63'ünü temsil etmekte iken, 1997 sayımında bu oran %4.97'ye, 1999'da ise %6'ya yükselmiş, ortalama yaşam beklentisi kadınlarda 76, erkeklerde ise 71 yıla ulaşmıştır (9-11). Yaşlı popülasyondaki bu artış, YBÜ›ne yatışı gerektiren yaşlı hastaların da oranını artırmaktadır ve YBÜ›ne yatan hastaların %46'sını yaşlı hastaların oluşturduğu bildirilmektedir (12). Yoğun bakıma yatan hastalarda ileri yaşla birlikte mortalitede anlamlı bir artış görülmektedir (13)(14)(15)(16).…”

Section: Discussionunclassified

“…Ferritin depo demirin %65'ni oluşturan, demir ve apoprotein komleksidir. Karaciğer hasarında ve hemotolojik malignitelerde yükselebileceği gibi inflamasyon varlığında akut faz yanıt olarak yükselir (42). Aulbert ve Steffens tarafından yapılan çalışmada; 535 hastada ferritin konsantrasyonlarına bakılmış.…”

Section: Değerlerunclassified

“…%54 hastada ferritin konsantrasyonu yüksek bulundu. Serum ferritin konsantrasyonunun hastalığın aktivitesini yakinen takip ettiği, tedavi öncesi artmış serum ferritin seviyelerinin tedavi sonrası tamamen normalleştiği görülmekte, remisyonda olan hastaların ferritin seviyelerinin normalleştiği, progresyonda ise tekrar artışa geçtiği ifade edilmektedir (42). Bizim çalışmamızda da eksitus olan hastalarda ferritin düzeylerinin taburcu olan hasta grubuna göre yüksek olduğu, ferritin düzeyi yüksekliği ile mortalite arasında istatistiksel olarak anlamlı bir ilişki olduğu bulundu.…”

Section: Değerlerunclassified

See 1 more Smart Citation

The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service

Uluoz¹,

Sebe²,

Ay³

et al. 2013

JAEM

View full text Add to dashboard Cite

Objective: In this study, we tried to determine the relationship between inflammatory reagents, acute phase reactants, GCS, APACHE-II, SAPS-II scores and mortality of the patients over the age of 55 hospitalised inthe internal medicine intensive care unit. Material and Methods: This study was planned as a prospective, randomized study and the patients hospitalized in the intensive care unit from the emergency medicine department were enrolled in this study following the ethics committee approval. A standard data collection form was prpeared to collect the data in a standard way. 48 (%65.8) male, 25 (%34.2) women and a total of 73 patients were included in our study. Blood samples were taken from each patient and white blood cell (WBC), hemoglobin, c-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), prothrombin time (PTZ), activated partial thromboplastin time (aPTT), albumin and ferritin levels were studied in our laboratory. Glasgow Coma Scale, SAPS-II and APACHE-II scores were calculated for each patient. "SPSS for Windows version 18" package program was used for statistical analysis of the data. Chi square test was used to compare categorical measures between the groups. Mann-Whitney U test and T-test were used to compare quantitative measurements between the groups. Results: There was no statistically significant difference in mean age among patients who died and survived . Mean duration of hospitalization inthe patient group who died was less than for the survived patients group but there was no statistically significant difference between groups. A significant relationship was found between mortality and the high levels of ferritin, aPTT, SAPS-II and the low levels of albümin, GCS. No significant relationship was found between mortality and leukocyte count, haemoglobin, PTZ, CRP, TNFalpha, IL-1, IL-6, IL-10 and APACHE-II score. Conclusion: SAPS-II, GCS, ferritin, albumin, aPTT measurements were determined to be used in the mortality estimation of the patients hospitalised in the intensive care unit. (JAEM 2013; 12: 13-8)

show abstract

Ferritin im Serum – Ein ‘Tumormarker’ bei malignen Lymphomen?

Cited by 19 publications

References 1 publication

Serum β2-Microglobulin for Staging and Monitoring of Multiple Myelomas and Other Non-Hodgkin Lymphomas

Serum β2-Microglobulin for Staging and Monitoring of Multiple Myelomas and Other Non-Hodgkin Lymphomas

Detection and Quantification of β-2-Microglobulin Using Mass Spectrometric Immunoassay

The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service

Contact Info

Product

Resources

About