Ferritin levels in critically ill patients with COVID-19: A marker of outcome?

Dimοpoulos, George; Sakelliou, Alexandra; Flevari, Aikaterini; Tzannis, Kimon; Giamarellos‐Bourboulis, Evangelos J.

doi:10.18332/pne/135958

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Elevated values of ferritin in COVID-19 patients reveals constant macrophage activation and is a marker of disease activity and patient outcome. 36,37 High ferritin values are related to the so called secondary haemophagocytic lymphohistiocytosis (sHLH), the second cause of death after ARDS in patients with severe COVID-19. 36 This seems to be related to the ability of the virus to bind Toll Like Receptors and to activate inflammasome through IL-1β, but the mechanism needs further elucidation.…”

Section: Discussionmentioning

confidence: 99%

“…36,37 High ferritin values are related to the so called secondary haemophagocytic lymphohistiocytosis (sHLH), the second cause of death after ARDS in patients with severe COVID-19. 36 This seems to be related to the ability of the virus to bind Toll Like Receptors and to activate inflammasome through IL-1β, but the mechanism needs further elucidation. 36 In our study, 56.5% of hospitalized patients had elevated ferritin values, whereas 74.3% of non-hospitalized patients had normal values.…”

Section: Discussionmentioning

confidence: 99%

“…36 This seems to be related to the ability of the virus to bind Toll Like Receptors and to activate inflammasome through IL-1β, but the mechanism needs further elucidation. 36 In our study, 56.5% of hospitalized patients had elevated ferritin values, whereas 74.3% of non-hospitalized patients had normal values. Ferritin average values (739.07 ng/ml) were extremely high in patients who died.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective analysis of COVID-19 patients in the region of Eastern Achaia, Greece, in a Primary and Secondary Healthcare Setting. Could initial laboratory findings and age prejudge patients’ outcome?

Xaplanteri

Zoitopoulos

Diamanti

et al. 2022

MRAJ

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Since December 2019 mankind is agonized over the deadly coronavirus disease 2019 (COVID-19) which is due to the novel coronavirus (2019-nCoV) or Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-cov-2). Methods: In this retrospective study, laboratory findings and demographic features form all confirmed COVID-19 patients who attended the Emergency Department of both branches of our hospital during the first semester of 2021 were collected and analyzed. The working hypothesis was that initial laboratory data at the time the patients seeked medical assistant for the first time, regardless of comorbidities and day of onset of symptoms, can help predict patients’ outcome. Demographic data and laboratory tests were compared between hospitalized and non-hospitalized patients. Results: Data of 270 patients were collected and analyzed retrospectively. 31 blood measurement parameters performed in both hospital branches were compared between hospitalized and non-hospitalized patients. Of those, WBC count (p=0.016), neutrophil percentage (p<0.001), lymphocyte percentage (p<0.001), platelet count (p=0.041), glucose (p<0.001), urea (p<0.001), creatinine (p<0.001), SGOT (p=0.024), CK (p<0.053), LDH (p<0.001), GGT (p<0.001), sodium (p<0.001), calcium (p<0.001), high sensitivity Troponin I (p<0.001), and ferritin levels (p<0.001), proved statistically significant. Regarding demographic data, age was significantly linked to patients’ survival. Conclusion: Our data suggest that common initial laboratory findings of COVID-19 patients who seek for the first-time medical assistant regardless of comorbidities and time from onset of symptoms can give clues to the patient outcome. Age is also important for patients’ survival. Especially in a Primary Health Care Setting, common blood parameters like WBC count, neutrophil and lymphocyte percentage, platelet count, glucose, urea, creatinine, SGOT, CK, LDH, GGT, sodium, calcium, high sensitivity Troponin I, and ferritin levels, could be really helpful to predict disease severity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retrospective analysis of COVID-19 patients in the region of Eastern Achaia, Greece, in a Primary and Secondary Healthcare Setting. Could initial laboratory findings and age prejudge patients’ outcome?

Xaplanteri

Zoitopoulos

Diamanti

et al. 2022

MRAJ

View full text Add to dashboard Cite

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“…The coronavirus disease (COVID- 19) is an infectious disease, caused by the SARS-CoV-2 virus which attacks the lung parenchyma and is a systemic illness with a significant mortality rate 1 .The angiotensin-converting enzyme 2 receptor (ACE2) on lung cell membranes attaches to the viral spike protein, allowing viral entrance into the cells 2…”

Section: Introductionmentioning

confidence: 99%

Low T3 Syndrome in severely ill patients with COVID-19 infection

Voulgareli*,

Zacharatos*,

Papageorgiou

et al. 2023

Pneumon

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with COVID-19 infection can present with no, mild or even with severe symptoms 3 .The thyroid gland is susceptible to COVID-19 infection because ACE2 receptors are present in the thyroid parenchyma 3 . Furthermore, Rotondi et al. 4 found that thyroid follicular cells showed ACE2 receptor mRNA expression, which indicates that SARS-CoV-2 may target the thyroid gland. Low levels of serum T3 and/or thyroxine (T4) without

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