Ferritin nanocage based delivery vehicles: From single-, co- to compartmentalized- encapsulation of bioactive or nutraceutical compounds

Ferritin nanocages as efficient nanocarriers and promising platforms for COVID-19 and other vaccines development

“…By modifying interactions at the subunit-subunit interface in ferritin we may not only control self-assembly to encapsulate cargoes of interest but also potentially regulate the release of the contents at acidic pH in a target cell environment. In addition to the pH-dependent disassembly/reassembly strategy in acidic compartments, other cargo delivery strategies include genetic or chemical conjugations and surface functionalization of ferritin using peptides, antibodies, and functional ligands, have been employed [ 101 ]. In addition to ferritin's natural function to oxidize and store iron, ferritin can bind several other metal ions, especially divalent cations [ 102 ].…”

Tailored Functionalized Protein Nanocarriers for Cancer Therapy: Recent Developments and Prospects

“…Fn is highly biocompatible, biodegradable, and has low toxicity, which are desirable properties of nanocarriers [ 18 ]. Owing to its sensitivity to pH, the nanocage-like structure of Fn facilitates various drug-loading techniques ( Table 1 ) [ 19 ]. For instance, Fn disassembles in strongly acidic environments but reassembles once the pH levels return to physiological levels.…”

Cost-Effective Preparation of Carbonic Anhydrase with Superior Performance for Assisting Amine and Amino Acid Ionic Liquid Blends in CO2 Absorption and Desorption

“…Ferritin, an iron-storage protein with excellent biocompatibility, can assemble into a highly symmetrical nanocage composed of 24 subunits . The nanocage is relatively robust and can withstand fairly severe environments, such as high temperature (82 °C) and alkalinity (pH = 12). , Therefore, compared to other tags, the fusion protein formed by ferritin is more easily expressed in Escherichia coli and can increase the production of the target enzyme. In addition, the rigid structure and the nanocage of ferritin can provide better protection for enzymes in a severe environment .…”