Ferrocene and glucose oxidase-installed multifunctional hydrogel reactors for local cancer therapy

Lee, Song Yi; Park, Jihye; Jeong, Da In; Hwang, ChaeRim; Lee, Junmin; Lee, KangJu; Kim, Hanjun; Cho, Hyun‐Jong

doi:10.1016/j.jconrel.2022.07.017

Cited by 31 publications

(19 citation statements)

References 63 publications

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“…The fluorescence probe method was employed to investigate the level of intracellular ROS. Briefly, 4T1 cells were incubated into 12-well plates at a density of 5 × 10 4 cells per well and incubated overnight in a CO 2 incubator.…”

Section: Methodsmentioning

confidence: 99%

Chitosan Thermosensitive Hydrogel Based on DNA Damage Repair Inhibition and Mild Photothermal Therapy for Enhanced Antitumor Treatment

et al. 2023

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The DNA damage repair of tumor cells limits the effect of photothermal therapy (PTT), and high temperatures induced by PTT can damage adjacent normal tissues. To overcome these limitations, we developed a novel composite hydrogel (OLA-Au-Gel) based on chitosan (CS) and β-glycerophosphate (β-GP), which encapsulated olaparib-liposomes (OLA-lips) and CS-capped gold nanoparticles (CS-AuNPs). OLA-Au-Gel achieved the combination of mild PTT (mPTT) by CS-AuNPs and tumor DNA damage repair inhibition by OLA. The hydrogel showed good biocompatibility, injectability, and photothermal response. Under near-infrared laser irradiation, OLA-Au-Gel inhibited the proliferation of tumor cells, induced the generation of reactive oxygen species in vitro, and effectively inhibited the growth of breast tumors in vivo. OLA-Au-Gel shows a promising application prospect for inhibiting tumor development and improving the antitumor effect. Collectively, we propose a novel strategy for enhanced antitumor therapy based on the combination of mPTT and DNA damage repair inhibition.

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Section: Methodsmentioning

confidence: 99%

Chitosan Thermosensitive Hydrogel Based on DNA Damage Repair Inhibition and Mild Photothermal Therapy for Enhanced Antitumor Treatment

et al. 2023

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“…Due to the cascaded catalytic reaction performed by CoMnFe-LDO and GOx, the composite hydrogel can realize satisfactory synergetic multifunctional tumor therapies, including chemodynamic therapy, starvation therapy, and PTT. Furthermore, Lee et al [ 275 ] developed a hyaluronic acid-based hydrogel for the treatment of breast cancer through multiple approaches including ferroptosis, PTT, chemodynamic therapy, and starvation therapy.…”

Section: Hydrogel-based Phototherapy Combined With Other Therapeutic ...mentioning

confidence: 99%

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Gan

Zhang

et al. 2023

Gels

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Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy.

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“…Finally, the prepared hydrogel reactors were injected peritumorally into 4T1 tumor and the most efficient anticancer results can be observed when combining with ST/CDT/PTT/ferroptosis under reduced dosing frequency condition. [ 194 ] However, peritumoral injection of hydrogel just covers the outer surface of tumor tissue and was hard to penetrate into the core region, and therefore tumor‐infiltrating systems have to be developed with the hope of improved therapeutic efficacies.…”

Section: Hyaluronic Acid‐based Hydrogels For Local Cancer Therapymentioning

confidence: 99%

Hyaluronic Acid‐Based Injectable Hydrogels for Wound Dressing and Localized Tumor Therapy: A Review

Yang

Wang

Peng

et al. 2022

Advanced NanoBiomed Research

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Hyaluronic acid (HA)‐based hydrogels are regarded as ideal candidates for wound dressing and localized cancer treatment due to the excellent biocompatibility, potential targeting property, and highly adaptable structure for modulated functionalities. Among the numerous advantages, the injectable property is probably one of the most important factors that determines the therapeutic efficiency of HA‐based hydrogels as wound dressings because it enables to complete filling of wound sites, in situ encapsulation of any bioactive molecule, and sufficient adherence to wounds. Meanwhile, HA‐based injectable hydrogels can be used as localized drug delivery systems for cancer therapy with significantly compromised systematic side effects. Therefore, there is clearly considerable scope to compose a timely review on this hot subject of research. However, few reviews, as per knowledge, focus on this topic. For this purpose, the recent notable efforts made on the use of HA‐based injectable hydrogels as new‐type wound dressings and localized drug delivery systems with a focus on chemistry adopted to achieve desirable properties and functions for optimal performances are summarized. The useful information and guidelines summarized here are believed to promote next generation and clinical translations of HA‐based injectable hydrogels with greater therapeutic efficiency for wound dressing and localized tumor therapy.

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Ferrocene and glucose oxidase-installed multifunctional hydrogel reactors for local cancer therapy

Cited by 31 publications

References 63 publications

Chitosan Thermosensitive Hydrogel Based on DNA Damage Repair Inhibition and Mild Photothermal Therapy for Enhanced Antitumor Treatment

Chitosan Thermosensitive Hydrogel Based on DNA Damage Repair Inhibition and Mild Photothermal Therapy for Enhanced Antitumor Treatment

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Hyaluronic Acid‐Based Injectable Hydrogels for Wound Dressing and Localized Tumor Therapy: A Review

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