Ferrocene modified analogues of imatinib and nilotinib as potent anti-cancer agents

Philipova, Irena; Mihaylova, Rositsa; Momekov, Georgi; Angelova, Rostislava; Stavrakov, Georgi

doi:10.1039/d3md00030c

RSC Med. Chem.

2023

DOI: 10.1039/d3md00030c

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Ferrocene modified analogues of imatinib and nilotinib as potent anti-cancer agents

Irena Philipova

Rositsa Mihaylova

Georgi Momekov

et al.

Abstract: The unique features of ferrocene and the need for development of targeted anticancer drugs, inspired the design, synthesis and biological evaluation of ferrocenyl modified tyrosine kinase inhibitors by replacing the...

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Cited by 2 publications

References 48 publications

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Synthesis and crystal structure of ferrocenyl benzothiazole derivatives

Stremski,

Bachvarova,

Statkova-Abeghe

et al. 2023

Journal of Organometallic Chemistry

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Synthesis and crystal structure of ferrocenyl benzothiazole derivatives

Stremski,

Bachvarova,

Statkova-Abeghe

et al. 2023

Journal of Organometallic Chemistry

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Exploring the Versatility of Ferrocene and its Derivatives: A Comprehensive Review

Jagdale,

Battellu,

Bhosale

et al. 2024

Biomed. Pharmacol. J.

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Ferrocene is a remarkable organometallic compound with an iron ion sandwiched between two cyclopentadienyl rings. This unique molecular structure and diverse characteristics such as improved solubility, altered reactivity, and enhanced biological activity make them potential candidates for drug development and diverse applications including cancer therapy. Additionally, ferrocene-based compounds exhibit a lower tendency to induce severe side effects, making them a safer option for cancer treatment. They also have shown potential in overcoming resistance encountered by platinum compounds in treating certain types of cancer. The three primary metabolic pathways for ferrocene include oxidation, cyclization catalyzed by acid, and hydroxylation, forming quinone methide, cyclic indene, and allylic alcohol, respectively. Building on this foundation, researchers have delved deeper into synthesizing and assessing novel ferrocene derivatives to enhance their effectiveness in addressing cancer and other illnesses. This review comprehensively examines potential derivative reactions, highlighting the possibilities for tailoring these compounds to achieve specific therapeutic objectives.

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Ferrocene modified analogues of imatinib and nilotinib as potent anti-cancer agents

Abstract: The unique features of ferrocene and the need for development of targeted anticancer drugs, inspired the design, synthesis and biological evaluation of ferrocenyl modified tyrosine kinase inhibitors by replacing the...

Cited by 2 publications

References 48 publications

Synthesis and crystal structure of ferrocenyl benzothiazole derivatives

Synthesis and crystal structure of ferrocenyl benzothiazole derivatives

Exploring the Versatility of Ferrocene and its Derivatives: A Comprehensive Review

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