Ferrocenyl chalcones versus organic chalcones: A comparative study of their nematocidal activity

Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans

“…To determine whether the solvent DMSO itself had any effect on C. elegans lifespan, worms were also exposed to a final concentration of 1% DMSO. This concentration of DMSO did not have any adverse biological effects on the nematodes in our study as reported by other authors (Attar et al 2011). …”

“…Young-Ah et al (2006) reported that the presence of hydroxyl group in 4´ position and the symmetry of hydroxylated substitutions in the B ring for flavonoids such as apigenin and its derivates could be responsible of larval growth inhibition of wild-type N2 worms. On the other hand, chalcones have been reported to have a broad range of biological activities such as antimalarial, antibacterial, antitumor, antioxidant, antihyperglycemic, anti-inflammatory, antileishmanial and anti-HIV (Attar et al 2011;Shenvi et al 2013;de Mello et al 2014). Liu et al (2003) reported that antileishmanial activity is favoured by chalcones with more hydrophilic character, between them 4´-hydroxychalcones.…”

“…Chalcones with different degrees of hydroxylation and methoxylation showed a significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis and the human malaria parasite, Plasmodium falciparum (Nowakowska 2007). Recently, Attar et al (2011), showed the nematocidal activity against C. elegans of ferrocenyl derivatives of chalcones and their organic analogs. Lee et al (2008) reported that some flavones have effects on C. elegans development.…”

Cyrhetrenyl chalcones: Synthesis, characterization and antimalarial evaluation

“…Considerable interest has been focused in their broad range of biological activities such as antibacterial [20], antitumour [21], antioxidant [22], antihyperglycemic [23] and anti-HIV [24]. Very recently, ferrocenyl chalcones have also been studied with regard to their nematocidal activities [25], fluorescent and electrochemical properties [26] as well as radicalscavenging capacities [27], molecular chemosensor activities [28] and as precursors for the syntheses of ferrocenyl pyrazolines [29,30]. Ferrocenyl chalcones have been conveniently prepared by a base-catalysed ClaiseneSchmidt condensation between acetylferrocene and an appropriately substituted aromatic aldehyde or ferrocene aldehyde and an appropriately substituted aromatic ketone.…”

First synthesis of ferrocenyl-substituted thiochalcones and their [4+2]-cycloadditions with acetylenic dienophiles

“…In a very recent review, ferrocene was referred to an exceptional molecule [10]. Diverse functionalizations of ferrocene are summarized in a very recent review [11], and chalcones containing a ferrocenyl moiety at both C(1) or C(3) positions are well known [12,13]. However, their thio-analogues, i.e.…”