Ferrocenylethenyl-substituted 1,3,4-oxadiazolyl-1,2,4-oxadiazoles: Synthesis, characterization and DNA-binding assays

Structural Determinants for the Mode of Action of the Imidazopyridine DS2 at d-containing g-Aminobutyric Acid Type A (GABAA) Receptors

“…The ester 41 was prepared as previously described 39 using ethyl 3-oxo-3-phenylpropanoate and subsequent cyclocondensation with 4-chloro-N'-hydroxybenzimidamide 40 GABAARs and as PAMs (applied together with a concentration of GABA corresponding to EC20), to evaluate intrinsic activity as well as selectivity (Figure 3). The compounds 27, 29, and 34 were found to have no activity at α 4 β 1 δ and were therefore not pursued further.…”

“…using ethyl 3-oxo-3-phenylpropanoate and subsequent cyclocondensation with 4-chloro-N'-hydroxybenzimidamide40 affording the 1,2Relationship of the Target Compounds at α4β1δ and α4β1γ2 GABAARs. The compounds were subjected to functional characterization in the FMP assay.…”

Design, Synthesis, and Biological Evaluation of 2‐(2‐Bromo‐3‐nitrophenyl)‐5‐phenyl‐1,3,4‐oxadiazole Derivatives as Possible Anti‐Breast Cancer Agents

“…Oxadiazole compounds as the bioisostere of benzimidazoles and thiazoles, imidazoles, tetrazoles, and triazoles have attracted increasing attention. Recently, numerous researches have been devoting to oxadiazole compounds as a medicinal agent with an intent to discover novel chemical scaffold compounds with low toxicity, high bioactive and excellent pharmacokinetic property . Thus, oxadiazoles are the important moieties that show more effective inhibition against various cancer cell lines such as breast cancer (MCF‐7, MDA‐MB231), skin cancer (HaCaT), cervical cancer (HeLa), liver cancer (HepG2), colorectal cancer (SW1116), human lung cancer cells (L2987, A549) and stomach cancer (BGC823) .…”

“…Recently, numerous researches have been devoting to oxadiazole compounds as a medicinal agent with an intent to discover novel chemical scaffold compounds with low toxicity, high bioactive and excellent pharmacokinetic property. [16,17] Thus, oxadiazoles are the important moieties that show more effective inhibition against various cancer cell lines such as breast cancer (MCF-7, MDA-MB231), skin cancer (HaCaT), cervical cancer (HeLa), liver cancer (HepG2), colorectal cancer (SW1116), human lung cancer cells (L2987, A549) and stomach cancer (BGC823). [18,19] In this aspect, there is a rise in the need to build novel anti-estrogen agents to combat estrogen receptorÀ ligand binding domain.…”

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

“…Among the various classes of heterocyclic compounds, 1,2,4oxadiazoles are noteworthy due to their usefulness in several applications, including industrial materials, products for agriculture (such as insecticides), and pharmaceutical and medicinal products, representing the largest applicability for these compounds [1][2][3][4][5]. e 1,2,4-oxadiazole nucleus is found in various synthetic drugs displaying a broad biological spectrum of activities, including anti-inflammatory [6,7], antifungal [8,9], antibiotic [10,11], antioxidant [12][13][14], anticonvulsant [15,16], and anticancer [17,18] properties.…”