Ferroptosis: A new view on the prevention and treatment of diabetic kidney disease with traditional Chinese medicine

Chen, Yu; Huang, Guodong; Qin, Ting; Zhang, Zechao; Wang, Huiling; Xu, Yitan; Shen, Xiaonan

doi:10.1016/j.biopha.2023.115952

Cited by 3 publications

(4 citation statements)

References 76 publications

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“…TCM inhibiting ferroptosis can intervene in various diseases or pathological conditions such as cerebral infarction (Hui et al, 2022), atherosclerosis ), Parkinson's Disease (Wu et al, 2021), among others. Chinese medicine suppresses cell ferroptosis through herbal compounds, monomers, and external treatments (acupuncture and moxibustion) (Chen et al, 2024).…”

Section: Replenishing the Deficienciesmentioning

confidence: 99%

“…Currently, "ferroptosis-TCM" research faces three major challenges. Firstly, studies on TCM are mostly limited to the treatment of active ingredients or herbal monomers, with few investigations into TCM compound prescriptions, proprietary Chinese medicines, and external treatment methods (Xie et al, 2023;Chen et al, 2024). Secondly, there are four broad mechanisms have been identified for inducing ferroptosis (Dixon et al, 2012): inhibition of the system Xc − (Sun et al, 2023), inhibition/ degradation/inactivation of GPx4 (Wang X. et al, 2023), depletion of reduced coenzyme Q 10 , and (Friedmann Angeli et al, 2019) induction of lipid peroxidation through peroxides, iron, or polyunsaturated fatty acid overload.…”

Section: Future Development Prospectsmentioning

confidence: 99%

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Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Cao,

Wei,

Yue

et al. 2024

Front. Pharmacol.

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In the past 11 years, there has been a surge in studies exploring the regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in comprehensive scientometric analysis and scientific mapping research, especially in tracking the evolution, primary contributors, and emerging research focal points. This study aims to comprehensively update the advancements in targeting ferroptosis with various TCMs during the previous 11 years. The data, covering the period from 1 January 2012, to 30 November 2023, were retrieved from the Web of Science database. For in-depth scientometric and visualized analyses, a series of advanced analytical instruments were employed. The findings highlight China’s predominant role, accounting for 71.99% of total publications and significantly shaping research in this domain. Noteworthy productivity was observed at various institutions, including Guangzhou University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, and Zhejiang University. Thomas Efferth emerged as the foremost author within this field, while Frontiers in Pharmacology boasted the highest publication count. This study pinpointed hepatocellular carcinoma, chemical and drug-induced liver injury, mitochondrial diseases, acute kidney injury, and liver failure as the most critical disorders addressed in this research realm. The research offers a comprehensive bibliometric evaluation, enhancing our understanding of the present status of TCM therapy in managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers and newcomers by accelerating access to vital information and fostering innovative concept extraction within this specialized field.

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Section: Replenishing the Deficienciesmentioning

confidence: 99%

Section: Future Development Prospectsmentioning

confidence: 99%

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Cao,

Wei,

Yue

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Current research indicates that certain active ingredients from natural plant ingredients can target the inhibit ferroptosis, thereby attenuating diabetes-induced tubular and glomerular damage as well as renal fibrosis, ultimately serving as a potential treatment for DN ( 132 – 134 ). Studies suggest that certain drugs or bioactive substances can mediate the occurrence and development of DN by modulating ferroptosis ( 135 ). Nobiletin ( 136 ) upregulates NRF2, enhancing the antioxidant stress capacity in the kidneys of diabetic mice.…”

Section: Ferroptosis and Kidney Diseasementioning

confidence: 99%

“…Moreover, pretreatment with nobiletin can reverse mitochondrial morphological changes induced by diabetic ferroptosis, delaying the progression of DN. The ACSL4 inhibitor rosiglitazone (Rosi) can also alleviate diabetic kidney damage by inhibiting ferroptosis ( 135 ). The role of certain traditional Chinese herbs in regulating ferroptosis is also noteworthy.…”

Section: Ferroptosis and Kidney Diseasementioning

confidence: 99%

Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Long,

Luo,

et al. 2024

Front. Immunol.

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Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and is characterized by the accumulation of lipid peroxides to lethal levels. Ferroptosis involves multiple pathways including redox balance, iron regulation, mitochondrial function, and amino acid, lipid, and glycometabolism. Furthermore, various disease-related signaling pathways also play a role in regulating the process of iron oxidation. In recent years, with the emergence of the concept of ferroptosis and the in-depth study of its mechanisms, ferroptosis is closely associated with various biological conditions related to kidney diseases, including kidney organ development, aging, immunity, and cancer. This article reviews the development of the concept of ferroptosis, the mechanisms of ferroptosis (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, and MBOAT1/2 pathways), and the latest research progress on its involvement in kidney diseases. It summarizes research on ferroptosis in kidney diseases within the frameworks of metabolism, reactive oxygen biology, and iron biology. The article introduces key regulatory factors and mechanisms of ferroptosis in kidney diseases, as well as important concepts and major open questions in ferroptosis and related natural compounds. It is hoped that in future research, further breakthroughs can be made in understanding the regulation mechanism of ferroptosis and utilizing ferroptosis to promote treatments for kidney diseases, such as acute kidney injury(AKI), chronic kidney disease (CKD), diabetic nephropathy(DN), and renal cell carcinoma. This paves the way for a new approach to research, prevent, and treat clinical kidney diseases.

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Introduction of Honeycomb (Nidus Vespae) and Some of Its Most Important Pharmacological Benefits

Shahrajabian,

Sun

2024

CNF

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Background:: Nidus Vespae (honeycomb), which is a well-known traditional Chinese medicine, is the honey-comb of Polistes japonicus Saussure, Parapolybia varia Fabricius, or Polistes olivaceus (De Geer), and it is usually harvest in winter and autumn. Method:: Its chemical component is completely complex combining honey, pollen, royal jelly, and propolis and consequently has a significant number of bioactive components such as nitro compounds, flavonoids, and polyphenols. It has shown various pharmacological impacts, such as anti- inflammatory, anti-viral, anti-microbial, and anti-tumor effects. Result:: In this review article, all relevant papers from various scholars and researchers were searched in Science Direct, Google Scholar, PubMed, and Scopus. Honeycomb has various activities and numerous pharmacological benefits and health advantages, and it can be considered a valuable source of nutraceuticals, and an effective natural medicine and organic product. Conclusion:: In this mini-review, we have decided to discuss the importance of traditional treatment, and the pharmacological properties of Nidus Vespae

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Ferroptosis: A new view on the prevention and treatment of diabetic kidney disease with traditional Chinese medicine

Cited by 3 publications

References 76 publications

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Introduction of Honeycomb (Nidus Vespae) and Some of Its Most Important Pharmacological Benefits

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