2023
DOI: 10.3390/ijms242417279
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Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds

Giuseppe Tancredi Patanè,
Stefano Putaggio,
Ester Tellone
et al.

Abstract: Ferroptosis is a form of cell death that is distinguished from other types of death for its peculiar characteristics of death regulated by iron accumulation, increase in ROS, and lipid peroxidation. In the past few years, experimental evidence has correlated ferroptosis with various pathological processes including neurodegenerative and cardiovascular diseases. Ferroptosis also is involved in several types of cancer because it has been shown to induce tumor cell death. In particular, the pharmacological induct… Show more

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Cited by 9 publications
(8 citation statements)
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“…Ferroptosis is a regulated cell death driven by iron-dependent lipid peroxidation [ 18 , 38 ]. To further investigate how H 2 S protects from rotenone-induced ferroptosis, labile iron levels were measured with a ferrozine colorimetric assay.…”
Section: Resultsmentioning
confidence: 99%
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“…Ferroptosis is a regulated cell death driven by iron-dependent lipid peroxidation [ 18 , 38 ]. To further investigate how H 2 S protects from rotenone-induced ferroptosis, labile iron levels were measured with a ferrozine colorimetric assay.…”
Section: Resultsmentioning
confidence: 99%
“…Second, H 2 S protected mitochondrial dysfunctions induced by rotenone, as shown by improved mitochondrial membrane potential, ATP generation, and oxygen consumption. Third, H 2 S reversed the protein expressions of GPx4, ACSL4, and Alox12, three marker proteins in ferroptosis contributing to lipid peroxidation [ 35 , 36 , 38 ]. Fourth, the blockage of ferroptosis by a selective inhibitor Fer-1 showed similar effects as H 2 S for protecting rotenone-induced lipid peroxidation, mitochondrial dysfunctions, and cell death.…”
Section: Discussionmentioning
confidence: 99%
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“…Notably, ferroptosis features like iron accumulation, GSH depletion, lipid peroxidation, and an increase in ROS species have been observed in PD. Accordingly, inhibitors of ferroptosis have the potential therapeutic role to protect the nervous system in PD [ 89 , 90 , 91 ].…”
Section: Ferroptosis As a Biological Program: Features And General Me...mentioning
confidence: 99%
“…Based on these findings, several therapeutic perspectives have been explored. Among them are the ferroptosis inhibitors and Fe chelators, which have shown promising neuroprotective effects in HD models [16,[121][122][123].…”
Section: Iron (Fe) -Hdmentioning
confidence: 99%