Ferroptosis in female reproductive diseases: from potential pathogenesis to therapy

Abstract

Ferroptosis, a cohering network integrating iron, amino acids, lipids, and redox chemicals together，is a unique regulated cell death (RCD). Iron overload, excessive reactive oxygen species (ROS), and lipid peroxidation all contribute to the onset of ferroptosis. In recent years, a growing body of evidence suggests that ferroptosis is associated with some female reproductive diseases. The purpose of our review is to give a brief description of ferroptosis activation mechanism and relationship to female reproductive diseases including infertility, pregnancy associated diseases and ovarian cancer.