Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Zhou, Yuhang; Fang, Chaoyou; Xu, Houshi; Yuan, Ling; Liu, Yibo; Wang, Xiaoyu; Zhang, Anke; Shao, Anwen; Zhou, Danyang

doi:10.3389/fonc.2022.989896

Cited by 6 publications

(5 citation statements)

References 167 publications

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“…To date, the clinical applications of ferroptosis mechanisms are as follows: on the one hand, ferroptosis-related agonists or inhibitors are used as therapies for pancreatic cancer [150], liver cancer [151], gastric cancer [150], glioma [152], etc. A variety of experimental cellular and animal studies have demonstrated the use of iron death agonists and inhibitors for the treatment of renal disease.…”

Section: Possible Clinical Applications Of Ferroptosis Mechanisms In ...mentioning

confidence: 99%

Novel Insight into Ferroptosis in Kidney Diseases

Liu¹,

Liu²,

Zhou³

et al. 2023

Am J Nephrol

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Background: Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney stones, are an important part of the global burden, bringing a huge economic burden to people around the world. Ferroptosis is a type of nonapoptotic iron-dependent cell death caused by the excess of iron-dependent lipid peroxides and accompanied by abnormal iron metabolism and oxidative stress. Over the past few decades, several studies have shown that ferroptosis is associated with many types of kidney diseases. Studying the mechanism of ferroptosis and related agonists and inhibitors may provide new ideas and directions for the treatment of various kidney diseases. Summary: In this review, we discuss the differences between ferroptosis and other types of cell death such as apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features of the kidney, and ferroptosis-induced kidney injury. We also provide an overview of the molecular mechanisms involved in ferroptosis and events that lead to ferroptosis. Furthermore, we summarize the possible clinical applications of this mechanism among various kidney diseases. Key Message: The current research suggests that future therapeutic efforts to treat kidney ailments would benefit from a focus on ferroptosis.

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Section: Possible Clinical Applications Of Ferroptosis Mechanisms In ...mentioning

confidence: 99%

Novel Insight into Ferroptosis in Kidney Diseases

Liu¹,

Liu²,

Zhou³

et al. 2023

Am J Nephrol

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“…This system facilitates the exchange of glutamate and cysteine. Once inside the cell, cysteine 2 (Cys2) is converted into cysteine, which stimulates the production of the GPX4 substrate GSH (53). GPX4, a fundamental regulator of ferroptosis, may convert GSH to oxidized glutathione and reduce lipid hydroperoxides to lipid alcohols.…”

Section: Ferroptosismentioning

confidence: 99%

Research progress on ferroptosis in gliomas (Review)

Bo,

Mu,

Yang

et al. 2023

Oncol Lett

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Glioma is the most prevalent type of brain tumor characterized by a poor 5-year survival rate and a high mortality rate. Malignant gliomas are commonly treated by surgery, chemotherapy and radiotherapy. However, due to toxicity and resistance to chemoradiotherapy, these treatments can be ineffective. Anxiety and depression are highly prevalent in patients with glioma, adversely affecting disease prognosis and posing societal concerns. Ferroptosis is a type of non-apoptotic, iron-dependent cell death characterized by the accumulation of lethal reactive oxygen species produced by iron metabolism, and it serves a key role in numerous diseases. Regulation of iron phagocytosis may serve as a therapeutic strategy for the development of novel glioma treatments. The present review discusses the mechanisms underlying the occurrence and regulation of ferroptosis, its role in the genesis and evolution of gliomas, and its association with glioma-related anxiety and depression. By exploring potential targets for glioma treatment, the present review provides a theoretical basis for the development of novel therapeutic strategies against glioma.

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“…Given the connection to iron metabolism, ferroptosis-based interactions in proteogenomic analysis via heme signaling and peroxisome classifications [18,36,37]. Several agents, including temozolomide, target ferroptosis [38]. Its links to the lipidome will likely benefit from increasing analysis as connections between the metabolome and the lipidome and tumor resistance are growing in glioma.…”

Section: Emerging Pathway and Omic Signatures In Gliomamentioning

confidence: 99%

Attributing Meaning to Molecular Interaction Networks by Leveraging Clinical and Omic Data: The Missing Link between Tumor Biology and Treatment Strategies in Glioma

V. Krauze

2023

Molecular Biology and Treatment Strategies for Gliomas

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The pace of data growth in the molecular space has led to the evolution of sophisticated approaches to data aggregation and linkages, such as IPA, STRING, KEGG, and others. These tools aim to generate molecular interaction networks harnessing growing molecular data at all levels to link tumor biology knowledge to signaling pathways and matched analyses. Potentially actionable biomarkers, however, are evaluated based on clinically associated prognosis, and necessary computational approaches should be vetted for interpretability through a clinical lens. Intersectional clinical and computational expertise is needed to link omics, molecular interactions, and clinical data to address the missing link between tumor biology and treatment strategies.

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Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Cited by 6 publications

References 167 publications

Novel Insight into Ferroptosis in Kidney Diseases

Novel Insight into Ferroptosis in Kidney Diseases

Research progress on ferroptosis in gliomas (Review)

Attributing Meaning to Molecular Interaction Networks by Leveraging Clinical and Omic Data: The Missing Link between Tumor Biology and Treatment Strategies in Glioma

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