Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)

Luo, Linfeng; Mo, Guoheng; Huang, Deqiang

doi:10.3892/mmr.2021.11864

Cited by 27 publications

(15 citation statements)

References 126 publications

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“…Ferroptosis, one of the pathophysiological mechanisms of HIRI, is beneficial in reducing HIRI by inhibiting the occurrence of ferroptosis. Numerous studies have shown (Kim K M et al, 2020;Yamada N et al, 2020;Liu H et al, 2021;Luo L et al, 2021) that some drugs, such as ferrostatin-1, 1", "GSE15480", "Hub Gene".…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

et al. 2022

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Background: Primary liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death worldwide in 2020, and it ranks fifth in global incidence. Liver resection or liver transplantation are the two most prominent surgical procedures for treating primary liver cancer. Both inevitably result in HIRI, causing severe complications for patients and affecting their prognosis and quality of survival. Ferroptosis, a newly discovered mode of cell death, is closely related to HIRI. We used bioinformatics analysis to explore the relationship between the two further.Methods: The GEO database dataset GSE112713 and the FerrDB database data were selected to use bioinformatic analysis methods (difference analysis, FRGs identification, GO analysis, KEGG analysis, PPI network construction and analysis, Hub gene screening with GO analysis and KEGG analysis, intergenic interaction prediction, drug-gene interaction prediction, miRNA prediction) for both for correlation analysis. The GEO database dataset GSE15480 was selected for preliminary validation of the screened Hub genes.Results: We analysed the dataset GSE112713 for differential gene expression before and after hepatic ischemia-reperfusion and identified by FRGs, yielding 11 genes. These 11 genes were subjected to GO, and KEGG analyses, and PPI networks were constructed and analysed. We also screened these 11 genes again to obtain 5 Hub genes and performed GO analysis, KEGG analysis, intergenic interaction prediction, drug-gene interaction prediction, and miRNA prediction on these 5 Hub genes. Finally, we obtained preliminary validation of all these 5 Hub genes by dataset GSE15480.Conclusion: There is a close relationship between HIRI and ferroptosis, and inhibition of ferroptosis can potentially be a new approach to mitigate HIRI treatment in the future.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

et al. 2022

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“…Numerous studies have shown [30][31][32][33] that drugs such as ferrostatin-1, α-tocopherol, deferoxamine, and low-iron diets can reduce HIRI. Therefore, we also did related research, and we predicted the interactions of drug genes for the ve Hub genes screened.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

Sun

Xue

Guo

et al. 2022

Preprint

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Background Primary liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death worldwide in 2020. Liver resection or liver transplantation are the two most prominent modalities for the treatment of primary liver cancer, and both inevitably result in HIRI, causing serious complications for patients. Ferroptosis, a newly discovered mode of cell death, is closely related to HIRI. We further investigated the relationship between the two by means of bioinformatics analysis. Methods The GEO database dataset GSE112713 and FerrDB database data were selected for analysis using bioinformatic analysis methods (differential analysis, FRGs identification, GO analysis, KEGG analysis, PPI network construction and analysis, Hub gene screening with GO analysis and KEGG analysis, inter-gene interaction prediction, drug-gene interaction prediction, miRNA prediction). Results Volcano, Venn, bar chart, bubble chart, PPI network, and Cytoscape network plots were plotted. Conclusion There is a close relationship between HIRI and ferroptosis, and inhibition of ferroptosis could be a new approach to mitigate HIRI treatment.

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“…Obviously, GPX4 is likely to inhibit the progression of lung fibrosis by downregulation of the TGF-β1/VCAM-1 signaling pathway (Figure 1). (Luo et al, 2021). Besides, a substantial body of evidence indicates that the activation of GPX4…”

Section: Gpx4 Exerts a Protective Role In The Development Of Lung Fib...mentioning

confidence: 99%

“…Attractively, GPX4 is reported to block angiogenesis and delay formation and progression of HCC (Rohr‐Udilova et al, 2018), suggesting that GPX‐4 renders a key function in the progression of liver fibrosis. Zhang et al indicate that a decline of GPX‐4 is found in ischemia–reperfusion injury in the liver (Luo et al, 2021). Besides, a substantial body of evidence indicates that the activation of GPX4 and inhibition of the TGF‐β/P‐Smad pathway and EMT process induced by obacunone suppresses the levels of α‐SMA and collagen, eventually leading to the inhibition of tissue remodeling and alleviation of liver fibrosis (Guan et al, 1995; Leonarduzzi et al, 1997).…”

Section: The Underlying Pathways Of Gpx4 In Fibrotic Diseasementioning

confidence: 99%

Function and regulation of GPX4 in the development and progression of fibrotic disease

Zhao-bing

Zhu

Liu

et al. 2022

Journal Cellular Physiology

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Fibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the development of fibrosis, including cytokines, hormones, and enzymes. Among them, glutathione peroxidase 4 (GPX4), as a selenoprotein antioxidant enzyme, is widely found in the embryo, testis, brain, liver, heart, and photoreceptor cells. Moreover, it is shown that GPX4 elicits diverse biological functions by suppressing phospholipid hydroperoxide at the expense of decreased glutathione (GSH), including loss of neurons, autophagy, cell repair, inflammation, ferroptosis, apoptosis, and oxidative stress. Interestingly, these processes are intimately related to the occurrence of fibrotic disease. Recently, GPX4 has been reported to exhibit a decline in fibrotic disease and inhibit fibrosis, suggesting that alterations of GPX4 can change the course or dictate the outcome of fibrotic disease. In this review, we summarize the role and underlying mechanisms of GPX4 in fibrosis diseases such as lung fibrosis, liver fibrosis, kidney fibrosis, cardiac fibrosis, and myelofibrosis.

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Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)

Cited by 27 publications

References 126 publications

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injury

Function and regulation of GPX4 in the development and progression of fibrotic disease

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