Ferroptosis in plants: regulation of lipid peroxidation and redox status

Distefano, Ayelén Mariana; López, G.A.; Bauer, Victoria; Zabaleta, Eduardo; Pagnussat, Gabriela Carolina

doi:10.1042/bcj20210682

Cited by 17 publications

(13 citation statements)

References 76 publications

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“… 20 The accumulation of ROS is tightly controlled by the antioxidant system and has the potential to alter essential biomolecules such as proteins, lipids, DNA and monosaccharides. 21 Nadeem et al found that under LN, toxicity caused by an overaccumulation of NH 4 + in grains was neutralized by the induction of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) activities. 22 Zhu et al 23 found that N deficiency led to increased lipid peroxidation and SOD activity in cannabis cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Tolerance and adaptation characteristics of sugar beet ( Beta vulgaris L.) to low nitrogen supply

Liu

Yao

et al. 2022

Plant Signaling & Behavior

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Nitrogen (N) is an essential element required for sugar beet growth. Sugar beets with low N (LN) tolerance and high N use efficiency are excellent materials for breeding. Here, we comprehensively evaluated the morphological and physiological responses of nine sugar beet genotypes to LN supply. It was found that 0.5 mmol·L −1 N (LN) significantly influenced the performance of leaves and the topology of roots by reducing the bioproduction of chlorophyll a (Chl a) and soluble protein (SP) and the accumulation of N in leaves and roots (LNA and RNA), thus differentially restricting the growth (hypocotyl diameter, HD; root length, RL) and biomass (leaf and root fresh weight; LFW and RFW; leaf dry weight, LDW) of these sugar beets. Principal component and cluster analyses showed that 780016B/12 superior (F) exhibited excellent tolerance to LN; it had higher SOD activity (62.70%) and APX activity (188.92%) and a higher proline content (131.82%) than 92011 (G, LN sensitive). These attributes helped 780016B/12 superior (F) to better endure LN stress, and the morphology and N distribution changed to adapt to N deficiency, such that the root length increased by 112.48%, leaf area increased by 101.23%, and leaf nitrogen accumulation reached a peak of 14.13 g/plant. It seems that LN-tolerant genotypes increased their root length and surface area by reducing the difference in biomass, thereby expanding the contact between roots and soil, which was conducive to the absorption of nutrients (N) by sugar beets and helped distribute more assimilation products to the roots.

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Section: Introductionmentioning

confidence: 99%

Tolerance and adaptation characteristics of sugar beet ( Beta vulgaris L.) to low nitrogen supply

Liu

Yao

et al. 2022

Plant Signaling & Behavior

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“…The absorbance of the solutions was examined at 532 nm (A532) and 600 nm (A600) using 20% TCA as the blank. The MDA content was calculated as follows: (6) 532 600…”

Section: Studymentioning

confidence: 99%

“…High salt concentration in plant cells results in ion toxicity, osmotic stress, oxidative stress and loss of antioxidant system balance, with the inability to eliminate reactive oxygen species (ROS) 5 . An increase in abiotic stress damages DNA, lipids and proteins in plant cells, directly affecting growth and productivity and possibly death due to lipid peroxidation 6 . Osmotic stress and nutritional imbalance caused by excessive salt concentration in plant cells inhibit water absorption of soluble salts in the root zone, especially for Potassium (K + ) and Calcium (Ca + ) 7 .…”

Section: Introductionmentioning

confidence: 99%

Salinity Tolerance Evaluation of Rice (Oryza sativa L.) ‘Tubtim Chumphae’ Seedling and Early Vegetative Stage

Taratima¹,

Chaisuwan²,

Plaikhunto³

et al. 2023

Asian J. of Plant Sciences

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Background and Objective: Salinity is abiotic stress that affects rice growth and results in lower yields. This research studied the effects of salinity on Tubtim Chumphae rice growth. Materials and Methods: Seedlings were cultivated for 35 days in the soil before being stressed by salinity (0, 25, 50, 75 and 100 mM NaCl) for 4 weeks. Growth performance and some physiological traits were recorded weekly for 4 weeks. Results: Under salinity stress, fresh and dry weight of shoot and root, relative dry weight, plant length and root length all decreased as salt solution concentration increased. Electrolyte leakage percentage and malondialdehyde content increased when rice was exposed to the salt solution for 4 weeks, indicating that high salinity damaged the lipid membrane. The PCA results revealed positive correlations among growth parameters that negatively correlated with MDA content and electrolyte leakage. The HCA results confirmed the PCA biplot showing decreasing expression of growth parameters with rising salt stress levels, while MDA content and electrolyte leakage continuously increased. Results suggested MDA content and electrolyte leakage as indicators for salt stress in Tubtim Chumphae rice at seedling and early vegetative stage. Conclusion: Findings in this study indicated that Tubtim Chumphae rice plants can grow in slight to moderate salinity soil. Results will deliver advantageous data that can be integrated with additional agronomical characters in rice growth or breeding plans for abiotic stress-tolerant cultivars improvement.

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“…Due to its ease in giving and accepting electrons to take part in oxidation-reduction events, iron is an essential element for a wide range of fundamental biological processes. Yet when there is too much "free" iron present, it is equally poisonous [2]. In fact, this redox-active iron can accelerate the Fenton reaction, which damages cells by destroying their lipids, proteins, and nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis Signaling Pathways: Alzheimer's Disease

Maheshwari

2023

Horm Metab Res

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The involvements of iron metabolism, lipid peroxidation, and oxidative stress in Alzheimer's disease (AD) development have recently received a lot of attention. We also observe that these pathogenic occurrences play a key role in regulating ferroptosis, a unique regulatory cell death that is iron-dependent, oxidative, and non-apoptotic. Iron is a crucial component that makes up a subunit of the oxidase responsible for lipid peroxidation. A family of non-heme iron enzymes known as lipoxygenases (LOXs) can cause ferroptosis by oxidising polyunsaturated fatty acids in cellular membranes (PUFAs). Toxic lipid hydroperoxides are produced in large part by the iron in LOX active sites. Deferoxamine and deferiprone, two iron chelators, could also treat ferroptosis by eliminating the crucial catalytic iron from LOXs. Phospholipids containing polyunsaturated fatty acids are the main substrates of lipid peroxidation in ferroptosis, which is favourably controlled by enzymes like ACSL4, LPCAT3, ALOXs, or POR. Selective stimulation of autophagic degradation pathways leads to an increase in iron accumulation and lipid peroxidation, which promotes ferroptosis. We highlighted recent advancements in our understanding of ferroptosis signaling routes in this study. One form of regulated necrotic cell death known as ferroptosis has been linked to a number of diseases, including cancer, neurological disorders, and ischemia/reperfusion injury. Cerebrospinal fluid (CSF) ferritin may be a good indicator of the amount of iron in the brain because it is the main protein that stores iron.

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Ferroptosis in plants: regulation of lipid peroxidation and redox status

Cited by 17 publications

References 76 publications

Tolerance and adaptation characteristics of sugar beet ( Beta vulgaris L.) to low nitrogen supply

Tolerance and adaptation characteristics of sugar beet ( Beta vulgaris L.) to low nitrogen supply

Salinity Tolerance Evaluation of Rice (Oryza sativa L.) ‘Tubtim Chumphae’ Seedling and Early Vegetative Stage

Ferroptosis Signaling Pathways: Alzheimer's Disease

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