Ferroptosis in the ageing retina: A malevolent fire of diabetic retinopathy

Li, Si-Yu; Zhao, Na; Wei, Dong; Pu, Ning; Hao, Xiao-Na; Huang, Jie-Min; Peng, Guang-Hua; Tao, Ye

doi:10.1016/j.arr.2023.102142

Cited by 6 publications

(1 citation statement)

References 153 publications

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“…The RPE cell layer provides support and nourishment for photoreceptor cells, and the integrity of its tight junctions is crucial for the structure and function of the retina ( 286 ). Ferroptosis could disrupt these tight junctions, leading to fluid permeation between the retinal layers, which could compromise the stability of the retina ( 287 ). RPE cells are responsible for phagocytosing and digesting the membrane discs of the outer segments of photoreceptor cells, a critical component of the visual cycle.…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%